Mitigating Effect of Cow Urine against Chlorpyrifos Induced Oxidative Stress

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Authors

  • Shelly Sharma
     Department of Zoology, Guru Nanak Dev University, Amritsar - 143005, Punjab ,IN
  • Sukanya Mehra
     Department of Zoology, Guru Nanak Dev University, Amritsar - 143005, Punjab ,IN
  • Pooja Chadha
     Department of Zoology, Guru Nanak Dev University, Amritsar - 143005, Punjab ,IN

DOI:

https://doi.org/10.18311/ti/2023/v30i4/33071

Keywords:

Cow Urine, Chlorpyrifos, Oxidative Stress

Abstract

The present study was planned to evaluate the mitigating effect of cow urine against the detrimental effects induced by Chlorpyrifos (CPF), an organophosphate pesticide, in different tissues of rat. The LD50 was determined and 1/4th of LD50 i.e., 38mg/ kg b.wt was selected for treatment. Sexually mature rats weighing 120±10 g was orally administered with selected dose and cow urine. After 24, 48 and 72 hours biochemical analysis was done using different biomarkers in different tissues. In light of available data, it was deduced that CPF has propensity to cause marked perturbations in the antioxidant enzymes. Further, cow urine mitigated the oxidative stress induced by CPF in different tissues. Thus, this study emphasizes the importance of use of cow urine as a natural source of antioxidants which could be beneficial in the therapeutic world for the treatment of various disorders implicating oxidative stress.

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Published

2023-12-11

How to Cite

Sharma, S., Mehra, S., & Chadha, P. (2023). Mitigating Effect of Cow Urine against Chlorpyrifos Induced Oxidative Stress. Toxicology International, 30(4), 675–680. https://doi.org/10.18311/ti/2023/v30i4/33071

Issue

Volume 30, Issue 4, October-December 2023

Section

Articles

License

Copyright (c) 2023 Shelly Sharma, Sukanya Mehra, Pooja Chadha

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2023-02-20
Accepted 2023-07-07
Published 2023-12-11

 

References

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