Long Term Exposure with Indoxacarb in WLH Cockerels Produces Reproductive Toxicity and its Amelioration by Rhizome Powder of Shati (<i>Hedychium spicatum</i>)

Authors

  • Department of Veterinary Pharmacology & Toxicology, G. B. Pant University of Agriculture and Technology, Pantnagar, Uttrakhand
  • Department of Veterinary Pharmacology & Toxicology, G. B. Pant University of Agriculture and Technology, Pantnagar, Uttrakhand

Keywords:

Indoxacarb, Cockerel, Gandhpalaasi (<i>Hedychium spicatum</i>), Reproductive Toxicity.

Abstract

The toxic effects of indoxacarb on the reproductive organ of cockerel and protective effect of Gandhpalasi (Hedychium spicatum) were evaluated in this study. The dose of indoxacarb was selected on the basis of LD50 in cockerels (250mg/kg). The experimental birds were kept in deep litter system of housing and maintained on grower ration. Birds were sacrificedafter completion of 16 weeks feeding trial. The semen were collected for estimation of mass motility, sperm count and % dead sperm. The antioxidant biomarkers in testis were also estimated. Finally the microscopic and ultrastructure of the testes were seen comparatively in both indoxacarb intoxicated and HSRP treated cockerels. The significant (P<0.05) reduction in sperm count and mass motility in indoxacarb group II and simultaneous treatment with HSRP in group VI and VII showed significant (P<0.05) improvement which was at par with the control. The % dead sperm were increased significantly (P<0.05) in indoxacarb treated group II whereas in HSRP treated group VI and VII showed significant decline in dose dependent manner. The antioxidant biomarker were significantly (P<0.05) changes by indoxacarb intoxication but treatment HSRP produced significant (P<0.05) amelioration. At the time of microscopic and ultrastructure examination of testes showed changes in indoxacarb treated group II and in HSRP treated group VI and VII showed mild to moderate changes. It is concluded from the present study that the HSRP produced protective effect in indoxacarb induced reproductive toxicity and its amelioration by HSRP treatment.

Downloads

Download data is not yet available.

Published

2017-12-01

How to Cite

Choudhary, G. K., & Singh, S. P. (2017). Long Term Exposure with Indoxacarb in WLH Cockerels Produces Reproductive Toxicity and its Amelioration by Rhizome Powder of Shati (<i>Hedychium spicatum</i>). Toxicology International, 24(3), 269–275. Retrieved from https://www.informaticsjournals.com/index.php/toxi/article/view/21102

Issue

Section

Original Research