<i>Terminalia chebula</i> Attenuates DMBA/Croton Oil-Induced Oxidative Stress and Inflammation in Swiss Albino Mouse Skin

Authors

  • Department of Medical Elementology and Toxicology, Section of Molecular Carcinogenesis and Chemoprevention, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi
  • Department of Medical Elementology and Toxicology, Section of Molecular Carcinogenesis and Chemoprevention, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi
  • Department of Medical Elementology and Toxicology, Section of Molecular Carcinogenesis and Chemoprevention, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi
  • Department of Medical Elementology and Toxicology, Section of Molecular Carcinogenesis and Chemoprevention, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi
  • Department of Medical Elementology and Toxicology, Section of Molecular Carcinogenesis and Chemoprevention, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi
  • Department of Medical Elementology and Toxicology, Section of Molecular Carcinogenesis and Chemoprevention, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi
  • Department of Medical Elementology and Toxicology, Section of Molecular Carcinogenesis and Chemoprevention, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi
  • Department of Medical Elementology and Toxicology, Section of Molecular Carcinogenesis and Chemoprevention, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi

Keywords:

Cytokines, Inflammation, Proinflammatory Markers, <i>Terminalia chebula</i>, Skin Carcinogenesis.

Abstract

Objective: The present study was designed to investigate underlying molecular mechanism for antitumorigenic potential of Terminalia chebula (TC) against chemically-induced skin tumorigenesis in Swiss albino mice. It is used as herbal medicine because it exhibits antioxidant, anti-inflammatory, and anticarcinogenic activity. However, the précised underlying mechanism remains to be elucidated. Materials and Methods: In light of the important role of nuclear factor-kappaB (NF-κB), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (i-NOS), ornithine decarboxylase (ODC), proinflammatory cytokines, oxidative stress in carcinogenesis, chemopreventive efficacy of TC against 7,12-dimethylbenz[a] anthracene (DMBA), and croton oil-induced 2-stage skin carcinogenesis was studied in terms of cytoprotective antioxidant enzymes activity, lipid peroxidation (LPO), inflammatory responses, and expression of various molecular markers in skin tissues. Results: We found that topical application of TC at dose of 30 mg/kg b. wt. mouse effectively suppressed oxidative stress and deregulated activation of inflammatory mediators and tumorigenesis. Histological findings further supported the protective effects of TC against DMBA/croton oil-induced cutaneous damage. Conclusion: The findings of the present study suggest that the chemopreventive effect of TC is associated with upregulation of endogenous cytoprotective machinery and downregulation of inflammatory mediators (inhterleukin (IL)-6, COX-2, i-NOS, ODC, and NF-κB).

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Published

2015-04-01

How to Cite

Majed, F., Nafees, S., Rashid, S., Ali, N., Hasan, S. K., Ali, R., Shahid, A., & Sultana, S. (2015). <i>Terminalia chebula</i> Attenuates DMBA/Croton Oil-Induced Oxidative Stress and Inflammation in Swiss Albino Mouse Skin. Toxicology International, 22(1), 21–29. Retrieved from https://www.informaticsjournals.com/index.php/toxi/article/view/20306