Anti-ulcer Activities of Herbal Remedies as Alternative Therapy


  • Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat
  • Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat
  • Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat
  • Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat
  • Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, Changa, Anand - 388421, Gujarat
  • Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat



Digestive System, Medicinal Herbs, Peptic Ulcer, Proton Pump Inhibitors


Peptic ulcer is a disorder that commonly has an effect on the digestive system. It is a chronic illness which has impact on approximately, 10% of the mankind. The majority of current therapy regimens are based on western medicine. Proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists, which are commonly used to treat peptic ulcers, have been linked to side effects, relapses, and drug interactions. However, several investigations have shown that herbal medications can efficiently heal stomach ulcers in humans and animals using different processes. As a result, this review will focus on common plants with medicinal value which can be utilized to cure or prevent peptic ulcers.


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Malfertheiner P, Chan FK, McColl KE. Peptic ulcer disease. Lancet. 2009; 374(9699):1449-61. S0140-6736(09)60938-7

Narayanan M, Reddy KM, Marsicano E. Peptic ulcer disease and Helicobacter pylori infection. Mo Med. 2018; 115(3):219-24. PMid: 30228726.

Lanas A, Chan FKL. Peptic ulcer disease. Lancet. 2017; 390:613-24. 6736(16)32404-7

Søreide K, Thorsen K, Harrison EM, Bingener J, Møller MH, Ohene-Yeboah M, et al. Perforated peptic ulcer. Lancet. 2015; 386(10000):1288-98. S0140-6736(15)00276-7

Prasanthi C, Prasanthi N, Manikiran S, Rao NR. Focus on current trends in the treatment of Helicobacter pylori infection: An update. Situations. 2011; 9(1):9.

Rauws EA. Eradication of Helicobacter pylori cures duodenal ulcer disease. In Helicobacter Pylori and Gastroduodenal Pathology. Springer, Berlin, Heidelberg; 1993. p. 347-51.

Brooks FP. The pathophysiology of peptic ulcer disease. Dig Dis Sci. 1985; 30(11):15S-29S. BF01309381. PMid:4053922

Geetha A, Saranya P. A study on the gastroprotective effect of Andrographis paniculata and andrographolide in rats subjected to pylorus ligation. J Pharm Res. 2012; 5(2):787- 91.

Amandeep K, Robin S, Ramica S, Sunil K. Peptic ulcer: A review on etiology and pathogenesis. Int Res J Pharm. 2012; 3(6):34-8.

Javadzadeh Y, Hamedeyaz S. Floating drug delivery systems for eradication of Helicobacter pylori n treatment of peptic ulcer disease. Trends H pylori Inf. 2014; 1:13. https://doi. org/10.5772/57353

Adibkia K, Hamedeyazdan S, Javadzadeh Y. Drug release kinetics and physicochemical characteristics of floating drug delivery systems. Expert Opin Drug Deli. 2011; 8(7):891-903. 24. PMid:21506906

Asnaashari S, Khoei NS, Zarrintan MH, Adibkia K, Javadzadeh Y. Preparation and evaluation of novel metronidazole sustained release and floating matrix tablets. Pharm Dev Technol. 2011; 16(4):400-7. https://doi. org/10.3109/10837451003774393. PMid:20429828

Javadzadeh Y, Hamedeyazdan S. Novel drug delivery systems for modulation of gastrointestinal transit time. In Recent Advances in Novel Drug Carrier Systems, Intech Open Publisher; 2012.

Javadzadeh Y, Hamedeyazdan S, Adibkia K, Kiafar F, Zarrintan MH, Barzegar-Jalali M. Evaluation of drug release kinetics and physico-chemical characteristics of metronidazole floating beads based on calcium silicate and gas-forming agents. Pharm Dev Technol. 2010; 15(4):329-38. PMid:19694496

Fujino S, Suzuki Y, Tanaka T. Cost-benefit analysis of medicinal treatment for gastric ulcers. Long-term model including healing and recurrence. Health Policy. 1985; 5:45- 72.

Schunack W. Pharmacology of H2-receptor antagonists: an overview. J Int Med Res. 1989; 17:9A-16A.

Bright-Asare P, Habte T, Yirgou B, Benjamin J. Prostaglandins, H2-receptor antagonists and peptic ulcer disease. Drugs. 1988; 35:1-9. 00003. PMid:2905237

Xiao YL, Nie YQ, Hou XH, Xie PY, Fang JY, Yuan YZ, et al. The efficacy, safety and cost-effectiveness of hydrotalcite versus esomeprazole in on-demand therapy of NERD: A multicenter, randomized, open-label study in China. J Dig Dis. 2013; 14: 463-8. 2980.12069. PMid:23659834

The cost for treating gastric ulcer. Available from: URL:

Ballinger A, Smith G. COX-2 inhibitors vs. NSAIDs in gastrointestinal damage and prevention. Expert Opin Pharmacother. 2001; 2:31-40. https://doi. org/10.1517/14656566.2.1.31. PMid:11336566

Huang JQ, Sridhar S, Hunt RH. Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: A meta-analysis. Lancet. 2002; 359:14-22.

Noach LA, Bosma NB, Jansen J, Hoek FJ, van Deventer SJ, Tytgat GN. Mucosal tumor necrosis factor-alpha, interleukin- 1 beta, and interleukin-8 production in patients with Helicobacter pylori infection. Scand J Gastroenterol. 1994; 29:425-9. PMid:8036458

Wallace JL, Vong L. NSAID-induced gastrointestinal damage and the design of GI-sparing NSAIDs. Curr Opin Investig Drugs. 2008; 9:1151-6. PMid: 18951293.

Rates SM. Plants as source of drugs. Toxicon. 2001; 39:603- 13.

Yesilada E, Gürbüz I, Shibata H. Screening of Turkish antiulcerogenic folk remedies for anti-Helicobacter pylori activity. J Ethnopharmacol. 1999; 66:289-93. https://doi. org/10.1016/S0378-8741(98)00219-0

Falcão HS, Mariath IR, Diniz MF, Batista LM, Barbosa-Filho JM. Plants of the American continent with antiulcer activity. Phytomedicine. 2008; 15:132-46. phymed.2007.07.057. PMid:17904832

Kesari AN, Gupta RK, Singh SK, Diwakar S, Watal G. Hypoglycemic and antihyperglycemic activity of Aegle marmelos seed extract in normal and diabetic rats. J Ethnopharmacol. 2006; 107(3):374-9. https://doi. org/10.1016/j.jep.2006.03.042. PMid:16781099

Rana BK, Singh UP, Taneja V. Antifungal activity and kinetics of inhibition by essential oil isolated from leaves of Aegle marmelos. J Ethnopharmacol. 1997; 57(1):29-34. https://

Kothari S, Mishra V, Bharat S, Tonpay SD. Antimicrobial activity and phytochemical screening of serial extracts from leaves of Aegle Marmelos (Linn.). Acta Poloniae Pharmaceutica. 2011; 68(5):687-92. PMid: 21928713

Das SK, Roy C. The protective role of Aegle marmelos on aspirin-induced gastro-duodenal ulceration in albino rat model: A possible involvement of antioxidants. Saudi J Gastroenterol. 2012; 18(3):188. PMid:22626798. PMCid:PMC3371421

Verma M. Investigation on antiulcer activity of Aegle marmelos root as experimental, biochemical and histological study. J Pharm Res. 2010; 3:2523-8.

Park JM, Han YM, Kangwan N, Lee SY, Jung MK, Kim EH, et al. S-allyl cysteine alleviates nonsteroidal anti-inflammatory drug-induced gastric mucosal damages by increasing cyclooxygenase-2 inhibition, heme oxygenase-1 induction, and histone deacetylation inhibition. J Gastroenterol Hepatol. 2014; 29(Suppl S4):80-92. jgh.12730. PMid:25521739

Iimuro M, Shibata H, Kawamori T, Matsumoto T, Arakawa T, Sugimura T, et al. Suppressive effects of garlic extract on Helicobacter pylori-induced gastritis in Mongolian gerbils. Cancer Lett. 2002; 187(1-2):61-8. S0304-3835(02)00401-9

Trio PZ, You S, He X, He J, Sakao K, Hou DX. Chemopreventive functions and molecular mechanisms of garlic organosulfur compounds. Food Funct. 2014; 5(5):833- 44. PMid:24664286

Cañizares P, Gracia I, Gómez LA, de Argila CM, Boixeda D, García A, et al. Allyl?thiosulfinates, the bacteriostatic compounds of garlic against Helicobacter pylori. Biotechnol Prog. 2004; 20(1):397-401. bp034143b. PMid:14763870

Al-Howiriny T, Alsheikh A, Alqasoumi S, Al-Yahya M, ElTahir K, Rafatullah S. Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats. Pharm Biol. 2010; 48(7):786-93. https://doi. org/10.3109/13880200903280026. PMid:20645778

Zarei A, Ashtiyani SC, Vaezi GH. A study on the effects of the hydroalcholic extract of the aerial parts of Alhagi camelorum on prolactin and pituitary-gonadal activity in rats with hypercholesterolemia. Arch Ital Urol Androl. 2014; 86(3):188-92. PMid:25308581

Gharibn AM, Mard S. Gastroprotective effect of Alhagi camelorum on experimental gastric ulcer in rats. Pak J Med Sci. 2007; 32(4):570-3.

Shaker E, Mahmoud H, Mnaa S. Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn). Food Chem Toxicol. 2010; 48(10):2785-90. PMid:20633591

Hannan JM, Ali L, Khaleque J, Akhter M, Flatt PR, Abdel- Wahab YH. Antihyperglycaemic activity of Asparagus racemosus roots is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of cellular insulin action. Br J Nutr. 2012; 107(9):1316-23. https://doi. org/10.1017/S0007114511004284. PMid:21899804

Siram K, Priyambada S, Aryya N, Goel R. Gastroduodenal Ulcer Protective Activity of Asparagus Racemosus: An Experimental, Biochemical and Histological Study. J Ethnopharmacol. 2003; 86:1-10. S0378-8741(02)00342-2

Bopana N, Saxena S. Asparagus racemosus- Ethnopharmacological Evaluation and Conservation Needs. J Ethnopharmacol. 2007; 110:1-15. https://doi. org/10.1016/j.jep.2007.01.001. PMid:17240097

Goel R, Sairam K. Anti-Ulcer Drugs from indigenous sources with emphasis on Musa sapientum, Tamra bhasma, Asparagus racemosus and Zingiber officinale. Indian J Pharmacol. 2002; 34:100-10.

Shibata M, Yoshida R, Motohashi S, Fukushima M. Pharmacological studies on Bupleurum falcatum L. IV. Some pharmacological effects of crude saikosides, saikogenin A and syrupy residue. J Pharm Soc Jpn. 1973; 93(12):1660- 7. PMid:4798800

Yamada H, Ra KS, Kiyohara H, Cyong JC, Otsuka Y. Structural characterisation of an anti-complementary pectic polysaccharide from the roots of Bupleurum falcatum L. Carbohydrate Res. 1989; 189:209-26. https://doi. org/10.1016/0008-6215(89)84098-4

Swarnakar S, Ganguly K, Kundu P, Banerjee A, Maity P, Sharma AV. Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem. 2005; 280(10):9409-15. M413398200. PMid:15615723

Huang MT, Lysz T, Ferraro T, Abidi TF, Laskin JD, Conney AH. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 1991; 51(3):813-9. PMid: 21928713

Niederau C, Gopfert E. The effect of chelidonium-and turmeric root extract on upper abdominal pain due to functional disorders of the biliary system. Results from a placebo-controlled double-blind study. Medizinische Klinik. 1999; 94(8):425-30. BF03044726. PMid:10495621

Prucksunand C, Indrasukhsri B, Leethochawalit M, Hungspreugs K. Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn.) on healing of peptic ulcer. Southeast Asian J Trop Med Public Health. 2001; 32(1):208- 15. PMid: 11485087.

Leporatti ML, Ivancheva S. Preliminary comparative analysis of medicinal plants used in the traditional medicine of Bulgaria and Italy. J Ethnopharmacol. 2003; 87(2-3):123-42.

Ivancheva S, Nikolova M, Tsvetkova R. Pharmacological activities and biologically active compounds of Bulgarian medicinal plants. Phytochemistry: Adv Res. 2006; 8:87-103.

?or?evi? S, Petrovi? S, Dobri? S, Milenkovi? M, Vu?i?evi? D, Žiži? S, et al. Antimicrobial, anti-inflammatory, antiulcer and antioxidant activities of Carlina acanthifolia root essential oil. J Ethnopharmacol. 2007; 109(3):458-63. PMid:17011148

Yoshikawa M, Morikawa T, Li N, Nagatomo A, Li X, Matsuda H. Bioactive saponins and glycosides. XXIII. Triterpene saponins with gastroprotective effect from the seeds of Camellia sinensis-Theasaponins E3, E4, E5, E6, and E7. Chem Pharm Bull. 2005; 53(12):1559-64. https://doi. org/10.1248/cpb.53.1559. PMid:16327189

Morikawa T, Li N, Nagatomo A, Matsuda H, Li X, Yoshikawa M. Triterpene saponins with gastroprotective effects from tea seed (the seeds of Camellia sinensis). J Nat Prod. 2006; 69(2):185-90. PMid:16499314

Maity S, Vedasiromoni JR, Chaudhuri L, Ganguly DK. Role of reduced glutathione and nitric oxide in the black tea extract-mediated protection against ulcerogen-induced changes in motility and gastric emptying in rats. Jpn J Pharmacol. 2001; 85(4):358-64. jjp.85.358. PMid:11388638

Maity S, Vedasiromoni JR, Ganguly DK. Anti-ulcer effect of the hot water extract of black tea (Camellia sinensis). J Ethnopharmacol. 1995; 46(3):167-74. https://doi. org/10.1016/0378-8741(95)01245-9

Adhikary B, Yadav SK, Roy K, Bandyopadhyay SK, Chattopadhyay S. Black tea and the aflavins assist healing of indomethacin-induced gastric ulceration in mice by antioxidative action. Evid Based Complementary Altern Med. 2011. PMid:20953434. PMCid:PMC2952312

Krylova S, Vymyatnina Z, Zueva E, Amosova E, Razina T, Litvinenko V. Effects of Cichorium Intybus L. Root extract on secretory activity of the stomach in health and ulcer disease. Bull Exp Biol Med. 2015; 159(5):638-41. https://doi. org/10.1007/s10517-015-3035-1. PMid:26468023

Gürbüz ?, Üstün O, Ye?ilada E, Sezik E, Akyürek N. In vivo gastroprotective effects of five Turkish folk remedies against ethanol-induced lesions. J Ethnopharmacol. 2002; 83(3):241-4. 8741(02)00248-9

Lee SY, Shin YW, Hahm KB. Phytoceuticals: mighty but ignored weapons against Helicobacter pylori infection. J Dig Dis. 2008; 9(3):129-39. 2980.2008.00334.x. PMid:18956590

Kim DK, Lee JA, Kim YB, Lee KM, Hahm KB. A randomized controlled trial assessing Korea red ginseng treatment of Helicobacter pylori-associated chronic gastritis. Korean J Med. 2007; 72:20-8.

daCosta DiBonaventura M, Yuan Y, Wagner JS, Gilbert JL, Lescrauwaet B, Langley P. The burden of viral hepatitis C in Europe: a propensity analysis of patient outcomes. Eur J Gastroenterol Hepatol. 2012; 24(8):869-77. https://doi. org/10.1097/MEG.0b013e3283551dee. PMid:22617367

Uzor PF, Ebrahim W, Osadebe PO, Nwodo JN, Okoye FB, Müller WE, et al. Metabolites from Combretum dolichopetalum and its associated endophytic fungus Nigrospora oryzae—Evidence for a metabolic partnership. Fitoterapia. 2015; 105:147-50. fitote.2015.06.018. PMid:26136060

Asuzu IU, Onu OU. Anti-ulcer activity of the ethanolic extract of Combretum dolichopetalum root. Int J Crude Drug Res. 1990; 28(1):27-32. https://doi. org/10.3109/13880209009082770

Singh D, Singh B, Goel RK. Traditional uses, phytochemistry and pharmacology of Ficus religiosa: A review. J Ethnopharmacol. 2011; 134(3):565-83. https://doi. org/10.1016/j.jep.2011.01.046. PMid:21296646

Saha S, Goswami G. Study of anti-ulcer activity of Ficus religiosa L. on experimentally induced gastric ulcers in rats. Asian Pac J Trop Med. 2010; 3(10):791-3. https://doi. org/10.1016/S1995-7645(10)60189-7

Thorat S, Deshmukh D, Gaikwad D, Grampurohit N. Antiulcer effect on the ethanol extract of the bark & root of Ficus religoisa linn. In different experimental ulcer models in rats. Int J Pharm Sci Res. 2013; 4(3):1120-4.

Turpie AG, Runcie J, Thomson TJ. Clinical trial of deglydyrrhizinized liquorice in gastric ulcer. Gut. 1969; 10(4):299-302. PMid:4889526. PMCid:PMC1552833

Bafna PA, Balaraman R. Anti-ulcer and anti-oxidant activity of pepticare, a herbomineral formulation. Phytomedicine. 2005; 12(4):264-70. 2003.12.009. PMid:15898703

Dehpour AR, Zolfaghari ME, Samadian T, Vahedi Y. The protective effect of liquorice components and their derivatives against gastric ulcer induced by aspirin in rats. J Pharm and Pharmacol. 1994; 46(2):148-9. https://doi. org/10.1111/j.2042-7158.1994.tb03760.x. PMid:8021806

Rybczy?ski JJ, Davey MR, Miku?a A, editors. The Gentianaceae-volume 2: biotechnology and applications. Springer Berlin Heidelberg; 2015. https://doi. org/10.1007/978-3-642-54102-5

Niiho Y, Yamazaki T, Nakajima Y, Yamamoto T, Ando H, Hirai Y, et al. Gastroprotective effects of bitter principles isolated from Gentian root and Swertia herb on experimentally- induced gastric lesions in rats. J Nat Med. 2006; 60(1):82-8.

Navarrete A, Trejo-Miranda JL, Reyes-Trejo L. Principles of root bark of Hippocratea excelsa (Hippocrataceae) with gastroprotective activity. J Ethnopharmacol. 2002; 79(3):383-8.

Alanis AD, Calzada F, Cervantes JA, Torres J, Ceballos GM. Antibacterial properties of some plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders. J Ethnopharmacol. 2005; 100(1-2):153-7. https:// PMid:16005589

Matsuda H, Li Y, Murakami T, Yamahara J, Yoshikawa M. Protective effects of oleanolic acid oligoglycosides on ethanol-or indomethacin-induced gastric mucosal lesions in rats. Life Sci. 1998; 63(17):PL245-50. https://doi. org/10.1016/S0024-3205(98)00426-3

Saito H, Lee Y, Takagi K, Shibata S, Shoji J, Kondo N. Pharmacological studies of Panacis japonici rhizoma. Chem Pharm Bull. 1977; 25(5):1017-25. cpb.25.1017. PMid:264170

Mehta VB, Sharma VJ, Shaikh MF, Amin PD, Sathaye S. Evaluation of Antioxidant and immunomodulatory activity of Lagenaria vul-garis. Int J Res Pharm Sci. 2011; 2(3):393- 8.

Choudhary MK, Bodakhe SH, Gupta SK. Assessment of the antiulcer potential of Moringa oleifera root-bark extract in rats. J Acupunct Meridian Stud. 2013; 6(4):214-20. https:// PMid:23972244

Banerjee D, Maity B, Bauri AK, Bandyopadhyay SK, Chattopadhyay S. Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: A mechanistic exploration. J Pharm Pharmacol. 2007; 59(11):1555-65. PMid:17976268

Maity B, Chattopadhyay S. Natural antiulcerogenic agents: An overview. Curr Bioact Compd. 2008; 4(4):225-44.

Yeo M, Kim DK, Cho SW, Hong HD. Ginseng, the root of Panax ginseng CA Meyer, protects ethanol-induced gastric damages in rat through the induction of cytoprotective heatshock protein 27. Dig Dis Sci. 2008; 53(3):606-13. https:// PMid:17763949

Sun Y. Structure and Biological Activities of the Polysaccharides from the Leaves, Roots and Fruits of Panax Ginseng CA Meyer: An Overview. Carbohydr Polym. 2011; 85:490-9.

Debashish B, Sayanti B, Bandyopadhyay SK, Subrata C. Picrorhiza kurroa-phytochemical and pharmacological evaluation. J N Govil Ed. Standardization of herbal/ Ayurvedic formulations. 2009; 24:69-89.

Ali MZ, Janbaz KH, Mehmood MH, Gilani AH. Antidiarrheal and antispasmodic activities of Polygonum bistorta rhizomes are mediated predominantly through K+ channels activation. Bangladesh J Pharmacol. 2015; 10(3):627-34.

Al-Said MS, Ageel AM, Parmar NS, Tariq M. Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity. J Ethnopharmacol. 1986; 15(3):271-8. 8741(86)90165-0

Paul AS, Islam A, Yuvaraj P. Anti-Helicobacter pylori and cytotoxic activity of detoxified root of Plumbago auriculata, Plumbago indica and Plumbago zeylanica. J Phytopharm. 2013; 2(3):4-8.

Ittiyavirah SP, Paul AS. Gastroprotective effect of plumbagin and ethanolic extract of plumbaginales in experimentallyinduced ulcer. J HerbMed Pharmacol. 2016; 5(3):928.

De Pasquale R, Germano MP, Keita A, Sanogo R, Iauk L. Antiulcer activity of Pteleopsis suberosa. J Ethnopharmacol. 1995; 47(1):55- 8. https://doi. org/10.1016/0378-8741(95)01256-D

Germano MP, Sanogo R, Guglielmo M, De Pasquale R, Crisafi G, Bisignano G. Effects of Pteleopsis suberosa extracts on experimental gastric ulcers and Helicobacter pylori growth. J Ethnopharmacol. 1998; 59(3):167-72. https://doi. org/10.1016/S0378-8741(97)00109-8

Süleyman HA, Demirezer LO, Kuruüzüm-Uz A, Akçay FA. Gastroprotective and antiulcerogenic effects of Rumex patientia L. extract. Die Pharmazie. 2002; 57(3):204-5. PMid: 11933853

Süleyman HA, Kuruüzüm-Uz A. Effects of Rumex patientia root extract on indomethacine and ethanol induced gastric damage in rats. Die Pharmazie. 2004; 59(2):147-9. PMid: 15025185

De La Lastra CA, Martin MJ, Marhuenda E. Gastric antiulcer activity of silymarin, a lipoxygenase inhibitor, in rats. J Pharm Pharmacol. 1992; 44(11):929-31. https://doi. org/10.1111/j.2042-7158.1992.tb03239.x. PMid:1361540

Yamahara J, Mochizuki M, Fujimura H, Takaishi Y, Yoshida M, Tomimatsu T, et al. Antiulcer action of Sophora flavescens root and an active constituent. I. J Ethnopharmacol. 1990; 29(2):173-7. V

Kyogoku K, Hatayama K, Yokomori S, Saziki R, Nakane S, Sasajima M, et al. I. Anti-ulcer effect of isoprenyl flavonoids. II. Synthesis and anti-ulcer activity of new chalcones related to sophoradin. Chem Pharm Bull. 1979;27(12):2943-53. PMid:540332

Petersson J, Phillipson M, Jansson EA, Patzak A, Lundberg JO, Holm L. Dietary nitrate increases gastric mucosal blood flow and mucosal defense. Am J Physiol Gastrointest Liver Physiol. 2007; 292(3):G718-24. ajpgi.00435.2006. PMid:17082222

Goel RK, Pathak NK, Biswas M, Pandey VB, Sanyal AK. Effect of lapachol, a naphthaquinone isolated from Tectona grandis, on experimental peptic ulcer and gastric secretion. J Pharm Pharmacol. 1987; 39(2):138-40. https://doi. org/10.1111/j.2042-7158.1987.tb06962.x. PMid:2882001

Kim JE, Lee JY, Kang MJ, Jeong YJ, Choi JA, Oh SM, Lee KB, Park JH. Withaferin A inhibits Helicobacter pyloriinduced production of IL-1β in dendritic cells by regulating NF-κB and NLRP3 inflammasome activation. Immune Network. 2015; 15(6):269-77. in.2015.15.6.269. PMid:26770181. PMCid:PMC4700403

Umadevi M, Rajeswari R, Rahale CS, Selvavenkadesh S, Pushpa R, Kumar KS, Bhowmik D. Traditional and medicinal uses of Withania somnifera. Pharma Innov. 2012; 1(9, Part A):102-10.

Singh N, Bhalla M, de Jager P, Gilca M. An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. 2011; 8(5S):208-13. PMid:22754076. PMCid:PMC3252722

Yamahara J, Hatakeyama S, Taniguchi K, Kawamura M, Yoshikawa M. Stomachic principles in ginger. II. Pungent and anti-ulcer effects of low polar constituents isolated from ginger, the dried rhizoma of Zingiber officinale Roscoe cultivated in Taiwan. The absolute stereostructure of a new diarylheptanoid. Yakugaku Zasshi. 1992; 112(9):645- 55. PMid:1469612

Wahida B, Abderrahman B, Nabil C. Antiulcerogenic activity of Zizyphus lotus (L.) extracts. J Ethnopharmacol. 2007; 112(2):228-31. PMid:17408894

Bakhtaoui FZ, Lakmichi H, Megraud F, Chait A, Gadhi CE. Gastro-protective, anti-Helicobacter pylori and, antioxidant properties of Moroccan Zizyphus lotus L. J Appl Pharm Sci. 2014; 4(10):81-7. JAPS.2014.401015




How to Cite

Sen, D. B., Kumar Sen, A., Patel, K. P., Balaraman, R., Shah, U., & Maheshwari, R. A. (2022). Anti-ulcer Activities of Herbal Remedies as Alternative Therapy. Journal of Natural Remedies, 22(3), 318–329.



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