Analgesic Property of Different Extracts of Curcuma longa (Linn.): An Experimental Study in Animals


Affiliations

  • St. John's Medical College, Division of Clinical Trials, IPHCR, Bangalore, India
  • Natural Remedies Pvt. Ltd., Research and Development Centre, Bangalore, 560100, India

Abstract

Different extracts of Curcuma longa, code named as PC/CL/SWP05, CL/111107506 and PT/0606188, each at three doses 100, 200 and 400 mg/kg were evaluated for their analgesic activity using different animal models of analgesia. PT/0606188 exhibited significant analgesic activity in the tail flick test at 400 mg/kg one hour after administration. CL/111107506 exhibited significant analgesic activity in the tail withdrawal test, one hour after administration at a dose of 100 mg/kg. All the three extracts significantly reduced the number of writhes in the acetic acid test except for PT/0606188 at a dose of 100 mg/kg. PC/CL/SWP05 demonstrated only peripheral analgesic activity while CL/ 111107506 and PT/0606188 demonstrated both central and peripheral analgesic activities.

Keywords

Curcuma longa, Analgesic Activity, Mice.

Subject Discipline

Pharmacy and Pharmacology

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