Reversal of Hepato-renal Impairment Induced by Meloxicam Paracetamol Toxicity in a Labrador Dog

Authors

  • Veterinary Clinical Complex, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu
  • Department of Veterinary Medicine, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu
  • Veterinary Clinical Complex, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu
  • Veterinary Clinical Complex, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu
  • Department of Veterinary Medicine, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu
  • Department of Veterinary Medicine, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu
  • Department of Veterinary Medicine, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu
  • Department of Veterinary Medicine, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu
  • Department of Veterinary Medicine, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu

DOI:

https://doi.org/10.18311/ti/2021/v28i1/26394

Keywords:

Dog, Hepatotoxicity, Hyperbilirubinemia, Meloxicam, Paracetamol

Abstract

An 8 years old male Labrador dog was referred to Small animal Medicine Referral Clinic, Veterinary Clinical complex, Veterinary College and Research Institute, Orathanadu for fever, anorexia, hematemesis and melenic stools. The dog on treatment with 2 ml of Meloxicam Paracetamol combination IM, along with Injection Oxytetracycline and fluid therapy for 3 days by locally and did not respond to treatment thus was referred. Clinical dullness, lethargy, respiratory distress, visible mucosal jaundice, ecchymosis on ventral abdomen was noticed. Physical examination revealed, halitosis, ulceration in the tip of the tongue, dehydration, pre scapular LN enlargement, distended abdomen, fluid thrill and splenomegaly. Hematology revealed anemia and thrombocytopenia. Biochemical analysis revealed Hyperbilirubinemia, Elevated BUN, Creatinine, AST, ALT, ALP and hypoalbuminemia. Abdominal ultrasound reveled splenomegaly, focal hyperechoic liver parenchyma, cortex echogenicity of right kidney and perirenal fluid accumulation. ECG revealed peaked T wave. Radiography revealed hepatosplenomegaly. Hemato-biochemical alteration was monitored before and after therapy. Animal was managed with fluid therapy, Acetylcysteine, Amino acid and supportives and the dog had an uneventful recovery.

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Published

2021-03-24

How to Cite

Saravanan, M., Premalatha, N., Ramkumar, P. K., Kannan, K., Apoorva, R., Venkatesan, M., Jayalshmi, K., Yogeshpriya, S., & Senthilkumar, S. (2021). Reversal of Hepato-renal Impairment Induced by Meloxicam Paracetamol Toxicity in a Labrador Dog. Toxicology International, 28(1), 81–89. https://doi.org/10.18311/ti/2021/v28i1/26394

Issue

Section

Original Research