Study of Nephrotoxic Potential of Acetaminophen in Birds

Jump To References Section

Authors

  • Departments of Veterinary Pharmacology and Toxicology, KVAFSU, Hebbal, Bangalore ,IN
  • Departments of Veterinary Pharmacology and Toxicology, KVAFSU, Hebbal, Bangalore ,IN
  • Veterinary Pathology, Veterinary College, KVAFSU, Hebbal, Bangalore ,IN
  • Departments of Veterinary Pharmacology and Toxicology, KVAFSU, Hebbal, Bangalore ,IN
  • Veterinary Faculty Clinics, Ningarhar University, Daronta Jalalabad, Ningarhar, Afghanistan ,AF

Keywords:

Acetaminophen, birds, diclofenac, nephrotoxicity
Neuroscience

Abstract

The present study was designed to evaluate the effect of acetaminophen on kidneys of birds by comparison with diclofenac that is used as positive control. The birds of Group I served as negative control and received normal saline, whereas Group II birds received diclofenac injection (2.5 mg/kg IM) and Group III birds received acetaminophen injection (10 mg/kg IM) for a period of seven days daily. The birds treated with diclofenac showed severe clinical signs of toxicity accompanied with high mortality and significant increase (P<0.001) in serum creatinine and uric acid concentration. The creatinine and uric acid concentrations were consistent with gross and histopathological findings. The negative control and acetaminophen-treated groups showed no adverse clinical signs, serum creatinine and uric acid concentrations were normal, and no gross or histopathological changes in kidneys were observed. Thus, it was concluded that acetaminophen can be used for treatment in birds without any adverse effect on kidneys.

Downloads

Download data is not yet available.

Published

2018-05-16

How to Cite

Jayakumar, K., Mohan, K., Swamy, H. D. N., Shridhar, N. B., & Bayer, M. D. (2018). Study of Nephrotoxic Potential of Acetaminophen in Birds. Toxicology International, 17(2), 86–89. Retrieved from https://www.informaticsjournals.com/index.php/toxi/article/view/21184

Issue

Section

Original Research
Received 2018-05-15
Accepted 2018-05-15
Published 2018-05-16

 

References

Ng LE, Halliwell B, Wong KP. Nephrotoxic cell death by diclofenac and meloxicam. Biochem Biophys Res Commun 2008;369: 873-7.

Swetha R, Jayakumar K, Narayanaswamy HD, Lokesh LV, Muniappan N. Paper presented at V Annual Conference of Indian Society of Veterinary Pharmacology and Toxicology, Chennai. 24-26 November 2005.

Reddy NC, Anjaneyulu Y, Sivasankari B, Rao KA. Comparative toxicity studies in birds using nimesulide and diclofenac sodium. Environ Toxicol Pharmacol 2006;22:142-7.

Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout BA, et al. Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 2004;427:630-3.

Luna LG. Manual of Histopathological Staining Methods of the Armed Forces Instituite of Pathology. 3rd ed. New York: McGraw Hill Book Co.; 1968.

GraphPad Prism. Version 4.01 for Windows, GraphPad Software Inc., San Diego, California, USA.; 2004.

Uma CA, Vijayasarathi SK, Nalini TS, Sathyanarayana ML, Rao S. Pathology of gout in poultry. Indian J Vet Pathol 1999;23: 94-5.

Uma CA, Vijayasarathi SK, Gowda RN. Uric acid levels in blood and kidney tissue of gouty birds. Indian J Vet Pathol 1997;21: 106-8.

Lumeij JT. Avian clinical biochemistry. In: Kaneko JJ, Harvey JW, Bruss ML, editors. Clinical Biochemistry of Domestic animals. San Deigo, California: Academic press; 1997. p. 857-84.

Most read articles by the same author(s)