Dose"‘Dependent Olanzapine"‘Induced Myoclonus

Jump To References Section


  • ,IN
  • ,IN
  • ,IN


Dose"‘dependent, myoclonus, olanzapine


Second"‘generation antipsychotics (SGA), mainly clozapine have been reported to induce myoclonus. Although olanzapine"‘induced myoclonus is reported, dose"‘dependent response has not been described. We report dose"‘related olanzapine"‘induced myoclonus in an early onset schizophrenia patient. We also suggest certain management strategies for such adverse side effects.


Download data is not yet available.



How to Cite

Krishna Tikka, S., Pratap, A., & Kumar Sinha, V. (2018). Dose"‘Dependent Olanzapine"‘Induced Myoclonus. Toxicology International, 21(3), 335–336. Retrieved from
Received 2018-04-27
Accepted 2018-04-27
Published 2018-06-04



Lertxundi U, Hernandez R, Medrano J, Domingo"‘Echaburu S, Garcí­a M, Aguirre C. Antipsychotics and seizures: Higher risk with atypicals? Seizure 2013;22:141"‘3.

Praharaj SK, Venkatesh BG, Sarkhel S, Zia"‘ul"‘Haq M, Sinha VK.Clozapine"‘induced myoclonus: A case study and brief review.Prog NeuroPsychopharmacol Biol Psychiatry 2010;34:242"‘3.

Camacho A, Garcia"‘Navarro M, Martinez B, Villarejo A, Pomares E.Olanzapine"‘induced myoclonic status. Clinl Neuropharmacol 2005;28:145"‘7.

Rosen JB, Milstein MJ, Haut SR. Olanzapine"‘associated myoclonus. Epilepsy Res 2012;98:247"‘50.

Varma S, Bishara D, Besag FM, Taylor D. Clozapine"‘related EEG changes and seizures: Dose and plasma"‘level relationships. Ther Adv Psychopharmacol 2011;1:47"‘66.

Amann BL, Pogarell O, Mergl R, Juckel G, Grunze H, Mulert C, et al. EEG abnormalities associated with antipsychotics: A comparison of quetiapine, olanzapine, haloperidol and healthy subjects. Hum Psychopharmacol 2003;18:641"‘6.

Shiloh R, Nutt D, Weizmann A. Atlas of psychiatric pharmacotherapy. London: Martin Dunitz; 2000.

Pranzatelli MR. Serotonin and human myoclonus. Rationale for the use of serotonin receptor agonists and antagonists. Arch Neurol 1994;51:605"‘17.