Acute High Dose Lithium‑Induced Exacerbation of Obsessive Compulsive Symptoms


  • Central Institute of Psychiatry, Department of Psychiatry, Ranchi, Jharkhand, India


Obsessive compulsive disorder (OCD) is a chronic neuropsychiatric disorder whose pathophysiology is linked to serotonergic dysfunction. More recently, the role of glutamate has also been posited. Lithium is used as an adjunctive for the treatment of OCD which is found to enhance serotonergic transmission. We present a case of OCD who was on stable dose of sertraline developed exacerbation of obsessive compulsive symptoms with acute high dose of lithium but improved after dose reduction.


Glutamate, lithium, obsessive compulsive disorder

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