Deuterium - A Natural Isotope to Combat Microbial Resistance

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Authors

  • Nirupama Panda
     Dr APJ Abdul Kalam Research Laboratory, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu ,IN
  • S. K. Zakki Uddin
     Dr APJ Abdul Kalam Research Laboratory, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu ,IN
  • G. V. Anjana
     Dr APJ Abdul Kalam Research Laboratory, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu ,IN
  • P. Ramalingam
     Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER) Hajipur District: Vaishali, Hajipur - 844102, Bihar ,IN
  • Senthilkumar Palaniappan
     Faculty of Pharmacy, Karpagam Academy of Higher Education, Pollachi Main Road, Eachanari Post, Coimbatore - 641021, Tamil Nadu ,IN
  • M. K. Mohan Maruga Raja
     Department of Pharmacognosy and Phytochemistry, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat – 391760 ,IN
  • M. K. Kathiravan
     Dr APJ Abdul Kalam Research Laboratory, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu ,IN

DOI:

https://doi.org/10.18311/jnr/2023/31386

Keywords:

Antimicrobial Resistance, Deuterium, Metronidazole, Pharmacokinetic Property

Abstract

Deuterated medicinal chemistry is an attempt to introduce deuterium into existing drug molecules through the replacement of hydrogen atoms (-H) with deuterium (-D). The process of deuteration is to reduce the rates of breaking the carbonhydrogen bond. If the carbon-hydrogen bond breaking is the rate-determining step in the biotransformation of the drug, the deuterated drug may show improved pharmacokinetic characteristics, such as a longer half-life, hence lowering the need for frequent dosing. In this review, we discuss the improvement in the drug’s pharmacokinetic profile with deuterium. Further, this Deuterium exchange chemistry can reduce toxicity and be safe for human use. Also, the drugs experimented with using deuterium are discussed as how deuterated chemistry can help fight antimicrobial resistance. Beyond all, still, the design and development of a successful deuterated drug with acceptable efficacy is hence a challenge. The translation of hypotheses from laboratory experiments to clinical application and further to real-time practice is unpredictable. Also, long-term drug stability and toxicity studies for individual drugs are to be studied which may vary from patient to patient.

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Published

2023-06-13

How to Cite

Panda, N., Zakki Uddin, S. K., Anjana, G. V., Ramalingam, P., Palaniappan, S., Mohan Maruga Raja, M. K., & Kathiravan, M. K. (2023). Deuterium - A Natural Isotope to Combat Microbial Resistance. Journal of Natural Remedies, 23(2), 295–305. https://doi.org/10.18311/jnr/2023/31386

Issue

Volume 23, Issue 2, April 2023

Section

Review Articles

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Copyright (c) 2023 Nirupama Panda, S. K. Zakki Uddin, G. V. Anjana, P. Ramalingam, Senthilkumar Palaniappan, M. K. Mohan Maruga Raja, M. K. Kathiravan (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2022-10-03
Accepted 2023-03-29
Published 2023-06-13

 

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