Avena sativa’s Therapeutic Potential: Exploring Antiasthmatic Effects in Guinea Pig Asthma Model

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Authors

  • Anil Kumar Yerragopu
     Department of Pharmacology, SIMS College of Pharmacy, Guntur - 522509, Andhra Pradesh ,IN
  • V. L. Anusha
     Department of Pharmacology, SIMS College of Pharmacy, Guntur - 522509, Andhra Pradesh ,IN
  • Shaik Aslam
     Department of Pharmaceutics, Hindu College of Pharmacy, Guntur - 522002, Andhra Pradesh ,IN
  • A. Rajesh
     Department of Pharmaceutics, Hindu College of Pharmacy, Guntur - 522002, Andhra Pradesh ,IN
  • Y. Sirisha
     Department of Pharmaceutical Analysis, SIMS College of Pharmacy, Guntur - 522509, Andhra Pradesh ,IN
  • A. L. Harini
     Department of Pharmaceutical Analysis, SIMS College of Pharmacy, Guntur - 522509, Andhra Pradesh ,IN
  • Shaik Faizan Ali
     Department of Pharmacy Practice, Shri Vishnu College of Pharmacy, Kovvada - 534202, Andhra Pradesh ,IN

DOI:

https://doi.org/10.18311/ti/2024/v31i1/35855

Keywords:

Avena sativa, Asthma, Anti-Inflammatory, Antioxidative, Guinea Pig Model, Histamine, Ovalbumin

Abstract

Avena sativa (oat) has emerged as a potential therapeutic candidate for asthma, a global health challenge characterized by chronic airway inflammation. This research investigates the anti-asthmatic potential of the Hydro-Alcoholic Extract of Avena sativa (HAEAS) in a guinea pig asthma model induced by histamine and ovalbumin. The study explores the influence of HAEAS on oxidative stress markers, leucocytes, eosinophils, and histopathological changes in lung tissues. Results reveal that HAEAS, particularly at 400 mg/kg, significantly increases the latent period and percentage protection in histamine induced bronchospasm. In ovalbumin-sensitized guinea pigs, HAEAS demonstrates a notable reduction in total leucocyte count, eosinophils, neutrophils, and macrophages in bronchoalveolar lavage fluid. Moreover, HAEAS exhibits antioxidative effects by increasing superoxide dismutase levels and decreasing malondialdehyde levels. Histopathological analysis demonstrates a decrease in inflammatory cell infiltration, hyperplasia, and bronchoconstriction. This study highlights the potential of Avena sativa as a novel therapeutic avenue for asthma, offering anti-inflammatory and antioxidant benefits.

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Published

2024-02-28

How to Cite

Yerragopu, A. K., Anusha, V. L., Aslam, S., Rajesh, A., Sirisha, Y., Harini, A. L., & Ali, S. F. (2024). <i>Avena sativa’s</i> Therapeutic Potential: Exploring Antiasthmatic Effects in Guinea Pig Asthma Model. Toxicology International, 31(1), 101–109. https://doi.org/10.18311/ti/2024/v31i1/35855

Issue

Volume 31, Issue 1, January-March 2024

Section

Articles

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Copyright (c) 2024 Anil Kumar Yerragopu, V. L. Anusha, Shaik Aslam, A. Rajesh, Y. Sirisha, A. L. Harini, Shaik Faizan Ali

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2023-12-12
Accepted 2024-01-09
Published 2024-02-28

 

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