Comparative Evaluation of 2% Curcumin and 2% Aloe Vera Gel in the Management of Chronic Recurrent Oral Aphthous Ulcers: A Clinical Study
Keywords:Aloe Vera, Anti-Inflammatory, Aphthous Stomatitis, Curcumin, Immunomodulation, Recurrent Oral Aphthous Ulcers
AbstractChronic recurrent oral aphthous ulcers are the most common type of inflammatory efflorescence of the oral mucosa, with no known effective treatment. Turmeric, a rhizome of Curcuma longa, and Aloe vera (A.V.) are herbs with anti-inflammatory and immune stimulant effects, which could be of benefit. The aim of this study is to do comparative evaluation of curcumin and aloe vera gel in the management of chronic recurrent oral aphthous ulcers. A randomized double-blind case control study was conducted on 60 patients suffering with chronic recurrent oral aphthous ulcers after obtaining their informed consent. The patients were randomly allocated in 2% curcumin, 2% aloe vera gel group and group receiving placebo gel. Patients were asked to apply the gels three times a day for two weeks. The clinical assessment of the size, number of ulcer, time taken for ulcer healing ,patient's pain score and the diameter of surrounding inflammation after gel application were recorded after 1, 7 and 14 days. The statistical evaluation of the obtained data was done using SPSS software. The mean age group of patients was 20±4.68 years. The 2% aloe vera gel was found to be more effective in reducing the pain, inflammation and burning sensation. 2% Curcumin gel was found to be effective in decreasing the size and duration of healing of the ulcerative lesion.
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Altenburg A, Zouboulis CC. Current concepts in the treatment of recurrent aphthous stomatitis. Skin Therapy Letter. 2008; 13:1–4.
Hamman JH. Composition and applications of Aloe vera leaf gel. Molecules. 2008; 13:1599–616. https://doi.org/10.3390/molecules13081599. PMid: 18794775. PMCid: PMC6245421
Richardson J, Smith JE, McIntyre M, Thomas R, Pilkington K. Aloe vera for preventing radiation-induced skin reactions: A systematic literature review. Clinical Oncology (R Coll Radiol). 2005; 17:478–84. https://doi.org/10.1016/j.clon.2005.04.013. PMid: 16149293
Kaur S, Sharma R, Sarangal V, Kaur N, Prashar P. Evaluation of anti-inflammatory effects of systemically administered curcumin, lycopene and piperine as an adjunct to scaling and root planing: A clinical study. AYU. 2017; 38:117–21. https://doi.org/10.4103/ayu.AYU_63_17. PMid: 30254390 PMCid: PMC6153907
World Medical Association. Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. JAMA. 2013; 310(20):2191–4. https://doi.org/10.1001/ jama.2013.281053. PMid:24141714
Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: A component of tumeric (Curcuma longa). Journal of Alternative and Complementary Medicine. 2003; 9:161–8. https://doi.org/10.1089/107555303321223035. PMid: 12676044
Hosadurga RR, Rao SN, Jose J, Rompicharla NC, Shakil M, Shashidhara R. Evaluation of the efficacy of 2% curcumin gel in the treatment of experimental periodontitis. Pharmacognosy Research. 2014; 6:326–33. https://doi.org/10.4103/0974-8490.138287. PMid: 25276071. PMCid: PMC4166822
Madan J, Sharma AK, Singh R. Fast dissolving tablets of aloe vera gel. Tropical Journal of Pharmaceutical Research. 2009 Feb; 8(1):63–70. https://doi.org/10.4314/tjpr.v8i1.14713
Hishikawa N, Takahashi Y, Amakusa Y, Tanno Y, Tuji Y, Niwa H, et al. Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia. AYU. 2012 Oct–Dec; 33(4):499–504. https://doi.org/10.4103/0974-8520.110524. PMid: 23723666. PMCid: PMC3665200
Kandwal A, Mamgain RK, Mamgain P. Comparative evaluation of turmeric gel with 2% chlorhexidine gluconate gel for treatment of plaque induced gingivitis: A randomized controlled clinical trial. AYU 2015; 36:145–50. https://doi.org/10.4103/0974-8520.175537. PMid: 27011714. PMCid: PMC4784123
Kumar S, Singh NN, Singh A, Singh N, Sinha RK. Use of Curcuma longa L. Extract to stain various tissue samples for histological studies. AYU. 2014; 35:447–51. https://doi.org/10.4103/0974-8520.159027. PMid: 26195911. PMCid: PMC4492033
Gupta VK, Malhotra S. Pharmacological attribute of Aloe vera: Revalidation through experimental and clinical studies. AYU. 2012; 33:193–6. https://doi.org/10.4103/09748520.105237. PMid: 23559789. PMCid: PMC3611630 13. Surjushe A, Vasani R, Saple DG. Aloe vera: A short review. Indian Journal of Dermatology. 2008; 53:163–6. https://doi.org/10.4103/0019-5154.44785. PMid: 19882025. PMCid: PMC2763764
Salazar-Sanchez N, Lopez-Jornet P, Camacho-Alonso F, Sanchez-Siles M. Efficacy of topical Aloe vera in patients with oral lichen planus: A randomized double-blind study. Journal of Oral Pathology & Medicine. 2010; 39:735–40. https://doi.org/10.1111/j.1600-0714.2010.00947.x. PMid: 20923446
Babaee N, Zabihi E, Mohseni S, Moghadamnia AA. Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis. Dental Research Journal. 2012; 9(4):381–5.
Sudarshan R, Annigeri RG, SreeVijayabala G. Aloe vera in the treatment for oral submucous fibrosis - a preliminary study. Journal of Oral Pathology & Medicine. 2012; 41(10):755–61. https://doi.org/10.1111/j.1600-0714.2012.01168.x. PMid: 22650317
Puataweepong P, Dhanachai M, Dangprasert S, Sithatani C, Sawangsilp T, NarkwongL, et al. The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: A double-blind placebo-controlled study. Asian Biomedicine. 2009; 3(4):375–82.
Chandrasekaran CV, Sundarajan K, Edwin JR, Gururaja GM, Mundkinajeddu D, Agarwal A. Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction. Pharmacognosy Research. 2013; 5:71–9. https://doi.org/10.4103/0974-8490.110527. PMid: 23798880. PMCid: PMC3685767
Scully C, Gorsky M, Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis: A consensus approach. Journal of the American Dental Association. 2003; 134:200–7. https://doi.org/10.14219/jada.archive.2003.0134. PMid: 12636124
Jittapiromsak N, Sahawat D, Banlunara W, Sangvanich P, Thunyakitpisal P. Acemannan, an extracted product from Aloe vera, stimulates dental pulp cell proliferation, differentiation, mineralization, and dentin formation. Tissue Engineering. Part A. 2010; 16:1997–2006. https://doi.org/10.1089/ten.tea.2009.0593. PMid: 20088703
Deshmukh RA, Bagewadi AS. Comparison of effectiveness of curcumin with triamcinolone acetonide in the gel form in treatment of minor recurrent aphthous stomatitis: A randomized clinical trial. International Journal of Pharmaceutical Investigation. 2014; 4:138–41. https://doi.org/10.4103/2230-973X.138346. PMid: 25126527. PMCid: PMC4131385