Aldrin Induce Acute Toxicity at Enzymatic and m-RNA Expression Levels in Zebrafish

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Authors

  • R. C. Jhamtani
     Laboratory of Analytical and Molecular Toxicology (Forensic Chemistry and Toxicology Laboratory), Institute of Forensic Science, Gujarat Forensic Sciences University, Sector 09, Gandhinagar – 382007, Gujarat ,IN ORCID logo http://orcid.org/0000-0003-3127-1754
  • S. Shukla
     Laboratory of Analytical and Molecular Toxicology (Forensic Chemistry and Toxicology Laboratory), Institute of Forensic Science, Gujarat Forensic Sciences University, Sector 09, Gandhinagar – 382007, Gujarat ,IN ORCID logo http://orcid.org/0000-0002-0278-8052
  • R. Agarwal
     Laboratory of Analytical and Molecular Toxicology (Forensic Chemistry and Toxicology Laboratory), Institute of Forensic Science, Gujarat Forensic Sciences University, Sector 09, Gandhinagar – 382007, Gujarat ,IN ORCID logo http://orcid.org/0000-0002-7444-1605

DOI:

https://doi.org/10.18311/ti/2018/21411

Keywords:

Aldrin, Gene Expression, Organochlorine, Oxidative Stress, Zebrafish.
Environmental Toxicology

Abstract

Aldrin is a systematic toxicant, belongs to cyclodiene class of organochlorine pesticide and banned due to its toxic, bioaccumalative and persistent nature but still detected from environmental components. Present study includes the assessment of aldrin toxicity at two sublethal concentrations in zebrafish. A total 81 zebrafish were divided into three groups viz. group 1: Control, group 2 and 3: Exposed groups which were given 3 mg/mL and 6 mg/mL of aldrin, respectively for 24 hours. The markers of oxidative stress viz. antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) were examined in terms of biochemical activities and gene expression. Acute exposure of aldrin (both concentrations) caused significant alteration in antioxidant enzymes activities and gene expression in liver, kidney and brain tissues, which were more prominent in brain in concentration dependent manner. Study provides a baseline data to understand alterations in enzymatic activity and expression leading to toxic manifestation of aldrin in aquatic animals.

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Published

2019-05-15

How to Cite

Jhamtani, R. C., Shukla, S., & Agarwal, R. (2019). Aldrin Induce Acute Toxicity at Enzymatic and m-RNA Expression Levels in Zebrafish. Toxicology International, 25(1), 48–58. https://doi.org/10.18311/ti/2018/21411

Issue

Volume 25, Issue 1, January-March 2018

Section

Research Articles
Crossref
Scopus
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Europe PMC
Received 2018-06-02
Accepted 2018-08-16
Published 2019-05-15

 

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