<i>In Vitro</i> Anti-oxidant Effect of Vitamin E on Oxidative Stress Induced due to Pesticides in Rat Erythrocytes


  • Department of Chemistry, Bareilly College, Bareilly - 243 005, Uttar Pradesh
  • Department of Chemistry, Bareilly College, Bareilly - 243 005, Uttar Pradesh
  • Department of Zoology, Bareilly College, Bareilly - 243 005, Uttar Pradesh


Catalase, chlorphyrifos, endosulfan, erythrocytes, lipid peroxidation, superoxide dismutase, vitamin E


An attempt was made to study the antioxidant property of vitamin E in endosulfan and chlorpyrifos toxicity. Erythrocytes were collected from healthy rats and exposed to 1 ppm endosulfan and chlorpyrifos pesticides individually and also along with vitamin E treatment. Results showed that endosulfan was more toxic in comparison of chlorpyrifos. Activities of superoxide dismutase and catalase were significantly decreased, while lipid peroxidation and glutathione-S-transfarase were increased in comparison to the control values. The results of the present study suggest that vitamin E acts as an effective antioxidant for endosulfan and chlorpyrifos pesticide toxicity, in reducing oxidative stress burden.


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How to Cite

Saxena, R., Garg, P., & Jain, D. K. (2018). <i>In Vitro</i> Anti-oxidant Effect of Vitamin E on Oxidative Stress Induced due to Pesticides in Rat Erythrocytes. Toxicology International, 18(1), 73–76. Retrieved from https://www.informaticsjournals.com/index.php/toxi/article/view/21317



Original Research