Toxicological Evaluation of Pooled Selected Fractions of Mimosa invisa and Protective Effect of Herbal Decoction

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Authors

  • College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala - 680 651, Thrissur ,IN
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal sciences, Mannuthy, Thrissur, Kerala-680651 ,IN
  • College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala - 680 651, Thrissur ,IN
  • Centre of Excellence in Pathology, College of Veterinary and Animal sciences, Mannuthy, Thrissur, Kerala-680651 ,IN

Keywords:

Boerhaavia diffusa, Hygrophila auriculata, Mimosa invisa, Tribulus terrestris
Biotechnology

Abstract

The study was undertaken to evaluate the toxicity produced by the pooled selected fractions of Mimosa invisa in rabbits. An attempt was made to protect the animal from the toxicity using a decoction containing Hygrophila auriculata, Tribulus terrestris and Boerhaavia diffusa. Eighteen adult rabbits were divided into three groups of six animals each. Group I served as control. Group II received pooled fraction of M. invisa at 0.4 g/kg orally. Group III was administered with pooled fraction along with the decoction containing H. auriculata, T. terrestris and B. diffusa equivalent to 5 g/kg. The experiment was conducted for 20 days. Group II showed significant increase in biochemical parameters like alanine transaminase, aspartate transaminase, gamma glutamyl tranferase, creatine kinase, alkaline phosphatase, creatinine and urea, suggesting liver and kidney toxicity. Histopathological examination of the liver and kidney supported these findings. Heart also showed mild histopathological changes. Administration of decoction reversed the biochemical and histopathological changes, indicating the protective effect of decoction.

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Published

2018-05-21

How to Cite

P. T. A., U., Gopakumar, N., Nair, A. M. C., & Nair, N. D. (2018). Toxicological Evaluation of Pooled Selected Fractions of <i>Mimosa invisa</i> and Protective Effect of Herbal Decoction. Toxicology International, 18(1), 77–80. Retrieved from https://www.informaticsjournals.com/index.php/toxi/article/view/21277

Issue

Section

Original Research
Received 2018-05-18
Accepted 2018-05-18
Published 2018-05-21

 

References

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