Ameliorative Potential of Quercetin Against Paracetamol-induced Oxidative Stress in Mice Blood

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  • Departments of Pharmacology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, 243 202 ,IN
  • Departments of Pharmacology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, 243 202 ,IN
  • Division of Medicine, Indian Veterinary Research Institute, Izatnagar - 243 122, Bareilly, Uttar Pradesh ,IN
  • Departments of Pathology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly - 243 202 ,IN
  • Departments of Pharmacology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, 243 202 ,IN


Antioxidant, lipid peroxidation, oxidative stress, paracetamol, quercetin


The aim of the present study was to evaluate the ameliorative potential of quercetin (QC) against paracetamol (PCM)- induced oxidative stress and biochemical alterations in mice blood. A total of 36 mice were randomly allocated into six groups, six mice in each. Group I served as healthy controls, while groups II and III were administered with N-acetylcysteine (NAC) and QC alone respectively. Group IV was administered with PCM alone. Groups V and VI were administered with PCM on day 0 followed by NAC and QC, respectively, for 6 consecutive days. On day 7th blood samples were obtained and subjected for the assays of oxidative stress and serum biochemical panels. Erythrocytic lipid peroxides contents of alone PCM-intoxicated mice were significantly higher, while reduced glutathione contents were found to be significantly lower in comparison with the healthy controls. The activities of antioxidant enzymes were also found to be singnificantly lower in these mice. Additionally, significantly increased activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase, as well as levels of bilirubin, urea and creatinine were revealed by these mice. Postadministration with QC remarkably alleviated the over production of MDA and improved GSH levels in PCM-intoxicated mice blood. In addition, antioxidant enzymes; glutathione peroxidase, glutathione-S-transferase, superoxide dismutase and catalase activities were also improved significantly in these mice. QC had also considerably ameliorated the altered biochemical parameters toward normalcy. Thus, it can be concluded that QC may constitute a remedy against PCM-induced oxidative stress and reno-hepatic injuries.


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Singh, S., Singh, S. K., Kumar, M., Chandra, K., & Singh, R. (2018). Ameliorative Potential of Quercetin Against Paracetamol-induced Oxidative Stress in Mice Blood. Toxicology International, 18(2), 140–145. Retrieved from
Received 2018-05-17
Accepted 2018-05-17
Published 2018-05-18



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