Toxicology International

Effect of Tamra Bhasma (Calcined Copper) on Ponderal and Biochemical Parameters


Affiliations

  • Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Department of Rasa Shastra and Bhaishajya Kalpana, Jamnagar, Gujarat, India

Abstract

Introduction: Tamra Bhasma (TB) and its forms like Somnathi Tamra Bhasma (STB), etc., are in vogue since centuries in Ayurveda. The present study is carried out to evaluate the effect of TB and STB in different dose levels on ponderal and biochemical parameters in wistar strain albino rats to provide scientific basis for its safety profile. Materials and Methods: TB and STB were prepared as per the classical guidelines and administered to wistar strain albino rats for 45 consecutive days. Blood was collected and rats were sacrificed on the 46th day. Ponderal and biochemical parameters were studied. Results: Results showed significant decrease in serum cholesterol, High Density Lipoprotein (HDL) cholesterol, triglycerides, total protein, and serum alkaline phosphatase levels. Comparatively, all the differences in between the groups are insignificant and no pathological changes at ponderal and biochemical levels were observed. Conclusion: Based on these observations, it can be said that these formulations can be safely used in cases of hyperlipidemia.

Keywords

Bhasma, biochemical parameters, copper, ponderal parameters, Somnathi Tamra Bhasma, Tamra Bhasma

Full Text:

References

Wadekar MP, Rode CV, Bendale YN, Patil KR, Gaikwad AB, Prabhune AA. Preparation and characterization of a copper based Indian traditional drug: Tamra Bhasma. J Pharm Biomed Anal 2005;9:951‑5.

Kulkarni DA. Rasa Ratna Samucchaya. New Delhi: Meherchand Lachamandas publication; 2007. p. 100.

Centers for Disease Control and Prevention (CDCP). Lead poisoning associated with use of Ayurvedic medications–Five states, 2000‑2003. MMWR Morbidity Mortality Weekly Report 2004;53:582‑4.

Dargan PI, Gawarammana IB, Archer, JR, House, IM, Shaw D, Wood DM. Heavy metal poisoning from Ayurvedic traditional medicines: An emerging problem? Int J Environ Health 2008;2:463‑74.

Saper RB, Russell S, Phillips, Sehgal A, Khouri N, Davis RB, et al. Lead, Mercury, and Arsenic in US‑ and Indian‑Manufactured Ayurvedic Medicines Sold via the Internet. JAMA 2008;300:915‑23.

K Sathe, Ali U, Ohri A. Acute renal failure secondary to ingestion of Ayurvedic medicine containing mercury. Indian J Nephrol 2013;23:301‑3.

Mishra GS. Ayurveda Prakasha. Varanasi: Chaukhamba Bharati Academy; 2007. p. 373.

Sen GD. Bhaishajya Ratnavali. Varanasi: Chaukhamba Surbharati Prakashan; 2008. p. 671.

Sen GD. Bhaishajya Ratnavali. Varanasi: Chaukhamba Surbharati Prakashan; 2008. p. 6 69.

Mishra GS. Ayurveda Prakasha. Varanasi: Chaukhamba Bharati Academy; 2007. p. 368.

Tripathi YB, Singh VP. Role of Tamra Bhasma, an Ayurvedic preparation in the management of lipid peroxidation in liver of albino rats. Indian J Exp Biol 1996;34:66‑70.

Kulkarni DA. Rasa Ratna Samucchaya. New Delhi: Meherchand Lachamandas publication; 2007. p. 93.

Kulkarni DA. Rasa Ratna Samucchaya. New Delhi: Meherchand Lachamandas publication; 2007. p. 101.

Sharma S. Rasa Tarangini. New Delhi: Motilala Banarsidas; 2009. p. 418.

Mishra SN, Rasendra Chudamani. Varanasi: Chaukhamba Orientalia; 2009. p. 24 6.

Paget GE, Barnes JM. Evaluation of drug activities. In: Pharmacometrics. Vol. 1. London: Academic Press; 1964. p. 50.


Refbacks

  • There are currently no refbacks.