Dayak Onions (Eleutherine bulbosa (Mill.) Urb.) Bulbs Extracts Reduce the Blood Pressure of Ovariectomized Rats

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Blood Pressure, Dayak Onions, Eleutherinol, Naphthoquinone, Ovariectomized
Drug discovery, Herbal medicine


Background: Eleutherine bulbosa (Mill.) Urb. extract has eleutherinol that could bind with estrogen receptor alpha selectively, therefore it's a candidate for selective estrogen receptor modulator drugs. Objective: To determine the influence of 70% of ethanol extract of E. bulbosa (Mill.) Urb., bulbs on blood pressure of ovariectomized rats. Methods: To analyze the content of the E. bulbosa (Mill.) Urb., bulbs, thin layer chromatography of the extracts were performed using chloroform : methanol (7 : 1, v/v) as the mobile phase. Thirty-six female Sprague-Dawley rats were used for this study, they were divided into six groups: SHAM and ovariectomized both given vehicle; tamoxifen (1.8 mg/kg BW.) as the positive control; three doses of extract at 40, 60, and 90 mg/kg BW were administereted respectively. All groups were ovariectomized on day 1, except the SHAM group. Measurement of blood pressure was performed on the day before ovariectomy, every week after ovariectomy until 28 days before treatment by the extract and then every week after treatment by the extract. Results: Three weeks after treatment of ovariectomized rats by the dose of 90 mg/kg BW of E. bulbosa (Mill.) Urb., extracts, could reduce the systolic blood pressure level to 28.06%, the diastolic to 30.47%. Conclusion: 70% of ethanolic extracts E. bulbosa (Mill.) Urb., could recover the blood pressure of ovariectomized rats, particularly at 90 mg/kg.


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How to Cite

Bahtiar, A., & Chumala, D. Y. (2018). Dayak Onions (<I>Eleutherine bulbosa</I> (Mill.) Urb.) Bulbs Extracts Reduce the Blood Pressure of Ovariectomized Rats. Journal of Natural Remedies, 18(2), 49–54.



Received 2018-07-08
Accepted 2018-08-22
Published 2018-09-10



Mieszczanska HZ, Velarde GP. Management of cardiovascular disease in women. Springer-Verlag Berlin Heidelberg; 2014.

Hargrove GM, Junco A, Wong NCW. Hormonal regulation of apolipoprotein AI. Journal of Molecular Endocrinology. 1999; 22:103–11. Crossref. PMid:10194513

Goodman NF, Corbin RH, Ginzburg SB, Katz IA, Woode DE. AACE medical guidelines for clinical practice for the diagnosis and treatment of menopause. Endocrine Practice. Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2011; 17(Suppl 6):1–25.

Pinkerton, JV, Thomas S. Use of SERMs for treatment in postmenopausal women. Journal of Steroid Biochemistry and Molecular Biology. 2014; 142:142–154.

Amelia T, Pratiwi D, Romsiah, Tjahjono D. In Silico study of the component of Eleutherine americana MERR on human estrogen receptor alpha as potential anti-breast cancer. 3rd International Conference on Computation for Science and Technology (ICCST-3); 2014.

Galingging R. Dayak onion as a multifunctional medicinal plant. Bulletin on Research and Development of Industrial Plants in Central Kalimantan. 2009; 15(3):16–8.

Kotakemori M, Okada K. Thin-layer chromatography of some substituted naphthoquinones. Agricultural and Biological Chemistry. 1966; 1369(Mar):2–4.

Govoni KE, Wergedal JE, Chadwick RB, Srivastava AK, Mohan S. Prepubertal OVX increases IGF-I expression and bone accretion in C57BL/6J mice. American Journal of Physiology- Endocrinology and Metabolism. 2008; 295(5):E1172–80.

Douglas SM, Rebecca R, Vogel E, Mark C, Eyster KM. Effect of ovariectomy on blood pressure and venous tone in female spontaneously hypertensive rats. American Journal of Hypertension. 2008; 21(9):983–8.

Di Carlo C, Sardo ADS, Bifulco G, Tommaselli GA, Guerra G, Rippa E, Nappi C. Postmenopausal ovariectomized increases vasoconstrictor neuropeptides and decreases vasodilator neuropeptides content in arterial-wall autonomic terminations. Fertility and Sterility. 2007; 88(1):95–9.

Radwanska E. The role of reproductive hormones in vascular disease and hypertension. Steroids. 1993; 58(12):605–10.