An Investigation on Bone Mineral Density in Hyperprolactinemia

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  • Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi - 110029 ,IN
  • Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi - 110029 ,IN
  • Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi - 110029 ,IN



Body Mass Index, Bone Mineral Density, Dual-Energy X-ray Absorptiometry, Hyperprolactinemia, Macroprolactinemia


Hyperprolactinemia patients have been reported to have low Bone Mineral Density (BMD). This study aimed to compare bone mineral density and associated factors in hyperprolactinemia. A total of 35 hyperprolactinemia patients (>100ng/ mL serum prolactin levels) and 10 controls participated in study. Hyperprolactinemia cases were classified into macroprolactinemia and true hyperprolactinemia as determined by Poly-Ethylene Glycol precipitation. Serum levels of Prolactin, Estradiol, Calcium, Phosphate or Alkaline Phosphatase were measured. BMD was measured at lumbar vertebrae, left femur, and left forearm by dual energy x-ray absorptiometry (DXA) scan. The prevalence of osteopenia/osteoporosis was 50% in macroprolactinemia, 70% in true hyperprolactinemia and 60% in controls (statistical differences were insignificant; p = 0.517). Pearson correlation analysis did not find any significant correlation of Prolactin, Estradiol, Calcium, Phosphate or Alkaline Phosphatase with T score or Z score at lumbar spine, femur or forearm (wrist) region in hyperprolactinemia patients and controls. The only significant correlations were found between body mass index (BMI) and prolactin levels (r = 0.473, p = 0.003); and between BMI and total femur T score (r = 0.360, p = 0.015) and Z score (r = 0.362, p = 0.015). Mean BMI was also significantly high (p = 0.029) in hyperprolactinemia patients with normal DXA (28.7±5.3 kg/m2) compared to those with Osteopenia/Osteoporosis (24.7±4.8 kg/m2). There was no significant difference in incidence of osteopenia/ osteoporosis between macroprolactinemia and true hyperprolactinemia patients. The only significant correlation of BMD was found with BMI suggesting high BMI to be a protective factor against osteoporosis in hyperprolactinemia patients.


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How to Cite

Kaur Kalsi, A., Jain, M., & Halder, A. (2020). An Investigation on Bone Mineral Density in Hyperprolactinemia. Journal of Endocrinology and Reproduction, 24(2), 105–119.



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