Preliminary Evaluation of the Anti-Inflammatory and Anti-Hepatotoxic Activities of 'Parsley' <I>Petroselinum crispum</I> in Rats

Authors

  • T. A. Al-Howiriny
  • M. O. Al-Sohaibani
  • K. H. El-Tahir
  • S. Rafatullah

DOI:

https://doi.org/10.18311/jnr/2003/364

Keywords:

Parsley, <I>Petroselinum crispum</I>, Anti-Inflammatory, Anti-Hepatotoxicity, Arab Traditional Medicine.

Abstract

Objective: To study the anti-inflammatory and hepatoprotective properties of an ethanolic extract of Parsley 'Petroselinum crispum' leaves. Materials and methods: An ethanolic extract of Parsley was subjected for evaluation of anti-inflammatory and anti-hepatotoxic activities against inflammation induced by carrageenan and cotton pellet granuloma and hepatic damage induced by carbon tetrachloride, respectively in rats. Apart from enzymes, non-protein sulfhydryl (NP-SH) groups were also estimated in liver. Histopathological test on liver was carried out and phenobarbitone-induced sleeping time in mice was also measured in different groups. Results: The phytochemical screening of the extract revealed the presence of flavonoids, tannins, sterols and or triterpenes. The extract exhibited significant protection against carrageenan-induced inflammation, cotton pellet-induced granuloma and CCl4-induced hepatic damage. Conclusion: Petroselinum crispum exhibited significant anti-inflammatory and anti-hepatotoxic activities which merits further detailed investigations.

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Published

2003-01-01

How to Cite

Al-Howiriny, T. A., Al-Sohaibani, M. O., El-Tahir, K. H., & Rafatullah, S. (2003). Preliminary Evaluation of the Anti-Inflammatory and Anti-Hepatotoxic Activities of ’Parsley’ <I>Petroselinum crispum</I> in Rats. Journal of Natural Remedies, 3(1), 54–62. https://doi.org/10.18311/jnr/2003/364

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Articles