Bioactivity of Lantana camara Flowers: Antilithiatic and Nephroprotective Implications in Male Wistar Rats

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Authors

  • Keerthana Arra
     Department of Pharmaceutical Sciences, KL College of Pharmacy, Koneru Lakshmaiah Educational Foundation, Guntur - 522502, Andhra Pradesh ,IN
  • Rajeshwari Pasupula
     Department of Pharmaceutical Sciences, KL College of Pharmacy, Koneru Lakshmaiah Educational Foundation, Guntur - 522502, Andhra Pradesh ,IN
  • Anandam Singireddy
     Department of Pharmacy, Vijaya College of Pharmacy, Munuganoor, Hayatnagar, Hyderabad - 501511, Telangana ,IN

DOI:

https://doi.org/10.18311/jnr/2024/35140

Keywords:

Folk Medicine, Gentamicin, Nephrolithiasis, Nephroprotection, Verbenaceae

Abstract

Lantana camara is a well-known medicinal plant with various reported therapeutic compounds. This study explores the antilithiatic and nephroprotective effects of Lantana camara flower hydroalcoholic extract. Using animal models and cell culture, we assessed its impact on ethylene glycol-induced nephrolithiasis and gentamicin-induced nephrotoxicity. The ethylene glycol-induced nephrolithiasis model revealed elevated levels of calcium, phosphate, and oxalate, indicating the formation of calculi. Treatment with the hydroalcoholic extract resulted in a significant decrease in uric acid levels, reducing the likelihood of calculi formation. Additionally, the animals treated with the extract showed reduced levels of urea, and creatinine, indicating improved kidney function. The results highlighted the notable difference between the preventive and curative treatments. In the HEK-293 cell culture, the hydroalcoholic extract demonstrated a significant inhibition of abnormal cell morphology induced by gentamicin, a nephrotoxic drug. The extract also exhibited a marked improvement in cell growth compared to the standard treatment. The findings of this study provide substantial evidence supporting the antilithiatic and nephroprotective effects of the hydroalcoholic extract of Lantana camara flowers. The extract effectively reduced the risk of calculi formation, improved renal parameters, and demonstrated potential in mitigating drug-induced nephrotoxicity. These results validate the traditional claims regarding the efficacy of Lantana camara as a therapeutic agent for kidney-related disorders. The hydroalcoholic extract of Lantana camara flowers could serve as a valuable alternative treatment option, offering potential benefits in the management of lithiasis and nephrotoxicity.

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Published

2024-04-30

How to Cite

Arra, K., Pasupula, R., & Singireddy, A. (2024). Bioactivity of <i>Lantana camara</i> Flowers: Antilithiatic and Nephroprotective Implications in Male Wistar Rats. Journal of Natural Remedies, 24(4), 803–815. https://doi.org/10.18311/jnr/2024/35140

Issue

Volume 24, Issue 4, April 2024

Section

Research Articles

License

Copyright (c) 2024 Keerthana Arra, Rajeshwari Pasupula, Anandam Singireddy (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2023-09-19
Accepted 2024-02-20
Published 2024-04-30

 

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