Evaluation of Wound Healing Activity of Vernonia amygdalina Extract in Diabetic Rats

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Authors

  • AvijitAvijit Mazumder
     Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park II, Institutional Area, Greater Noida – 201306, Uttar Pradesh ,IN
  • Bhavani Pentela
     Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park II, Institutional Area, Greater Noida – 201306, Uttar Pradesh ,IN
  • Sanjana
     Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park II, Institutional Area, Greater Noida – 201306, Uttar Pradesh ,IN
  • Vikas Gupta
     Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park II, Institutional Area, Greater Noida – 201306, Uttar Pradesh ,IN

DOI:

https://doi.org/10.18311/jnr/2023/34089

Keywords:

Diabetic, Excision, Incision, Luteolin, Vernonia amygdalina

Abstract

Excision and incision wound models were used to evaluate the wound healing activity on Wistar albino rats by applying the topical application of a prepared ointment. The wound healing potential was assessed by measuring the rate of the epithelization period, wound contraction, wound breaking strength, and histopathological parameters reference with povidone iodine ointment as standard. Higher rate of wound contraction (****P<0.0001), decrease in the period of epithelization (**P<0.01) higher wound breaking strength (****P<0.0001), and favorable histopathological changes were observed with the ointment containing 5% and 10% hydro-ethanolic extract of leaves. The data of this study indicated that hydro-ethanolic Vernonia amygdalina extract of leaves exhibited potent wound healing effects thus the study can be extended in future for the study of phytoconstituents which are giving the wound healing effect.

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Published

2023-08-31

How to Cite

Mazumder, A., Pentela, B., Sanjana, & Gupta, V. (2023). Evaluation of Wound Healing Activity of <i>Vernonia amygdalina</i> Extract in Diabetic Rats. Journal of Natural Remedies, 23(3), 1145–1152. https://doi.org/10.18311/jnr/2023/34089

Issue

Volume 23 Issue 3 July 2023

Section

Short Communication

License

Copyright (c) 2023 AvijitAvijit Mazumder, Bhavani Pentela, Sanjana, Vikas Gupta (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2023-06-16
Accepted 2023-07-24
Published 2023-08-31

 

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