Pharmacological Investigation of Cajanus scarabaeoides in Different Animal Modelsof Diarrhoea


Affiliations

  • Shardchandra Pawar College of Pharmacy, Department of Pharmaceutical Sciences, Pune, Maharashtra, 410504, India
  • College of Pharmaceutical Sciences, Department of Pharmaceutical Science, Berhampur, Gangam, Orissa, India

Abstract

The different solvent extract of Cajanus scarabaeoides (Family: Fabaceae) was studied for its antidiarrhoeal properties in experimental diarrhoea, induced by castor oil and magnesium sulphate in rat. At the doses of 500 mg/kg per oral, the methanol extract showed significant antidiarrhoeal activity in castor oil model and magnesium sulphate-induced diarrhea. Where as the petroleum ether extract and chloroform extract did not show any such activity. The methanol extract also significantly, reduced the intestinal transit in charcoal meal test when compared to atropine sulphate (5 mg/kg; i.m.). The results showed that the methanolic extract of Cajanus scarabaeoides have a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine.

Keywords

Cajanus scarabaeoides, Antidiarrhoeal, Loperamide, Castor Oil, Magnesium Sulphate.

Subject Discipline

Pharmacy and Pharmacology

Full Text:

Refbacks

  • There are currently no refbacks.