Metformin - A Panacea Pharmaceutical Agent through convergence revolution initiative

Sonia Prabhakaran; Dhiviya Thirumal; Jolius Gimbun; Balu Ranganathan

doi:10.18311/jnr/2017/17938

Authors

Sonia Prabhakaran
Department of Biotechnology, Sri Venkateswara College of Engineering, Pennalur, Kancheepuram District, Sriperambudur - 602117, Tamil Nadu, India
Dhiviya Thirumal
Department of Medicine, Karpaga Vinayaga Institute of Medical Sciences and Research Center, Chinna Kolambakkam, Palayanoor P.O, Kanchipuram Dist, Madurantagam - 603308, Tamil Nadu, India
Jolius Gimbun
Faculty of Chemical and Natural Resources Engineering, University Malaysia Pahang, Gambang Campus, Gambang - 26300, Malaysia
Balu Ranganathan
Palms Connect Sdn Bhd, Shah Alam - 40460, Selangor Darul Ehsan, Malaysia

DOI:

https://doi.org/10.18311/jnr/2017/17938

Keywords:

Antineoplastic Drug, Breast Cancer, Clinical Trials, Metformin, Start-Up Company

Abstract

Metformin has been known to the mankind for centuries. Metformin is the first line of drug of choice for the treatment of type 2 diabetes. Initial pharmaceutical therapy was for treating the frequent urinal problem which is a primary manifestation of diabetes. At the time of writing, metformin as an intervention is looked into for cardiovascular risks, polycystic ovary syndrome and breast cancer. Annual demand for Metformin is 23,000 Metric tons per annum. Nano Drug Delivery Systems (NDDS) has embarked into Metformin controlled and targeted delivery for breast cancer, pancreatic cancer and non-small cell lung cancer. Clinical estimation of the biological fluids by the FDA approved diagnostic laboratories use LC-MS/MS where blood samples estimate Metformin as an intact molecule easing the pressure of clinical trials result. Metformin was manufactured by a less known and low profile Aoron pharmaceutical, France not aware of the block buster drug hence the potential of technology development start-ups can neither be underwritten nor underestimated even when there is a very high rate (~90%) of failed biotech/biomed start-up ventures. The bloom of the French lilac (metformin) to blossom and flower for the cure of breast cancer by convergence revolution initiative with the integration of academia, hospital, technology business incubator, multinational corporation with the deliverance of a start-up company

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