TY - JOUR AU - P. T. A., Usha AU - Gopakumar, N. AU - Nair, A. M. Chandrasekhran AU - Nair, N. Divakran PY - 2018/05/21 Y2 - 2024/03/28 TI - Toxicological Evaluation of Pooled Selected Fractions of Mimosa invisa and Protective Effect of Herbal Decoction JF - Toxicology International JA - TI VL - 18 IS - 1 SE - Original Research DO - UR - https://www.informaticsjournals.com/index.php/toxi/article/view/21277 SP - 77-80 AB - The study was undertaken to evaluate the toxicity produced by the pooled selected fractions of <em>Mimosa invisa</em> in rabbits. An attempt was made to protect the animal from the toxicity using a decoction containing <em>Hygrophila auriculata, Tribulus terrestris and Boerhaavia diffusa</em>. Eighteen adult rabbits were divided into three groups of six animals each. Group I served as control. Group II received pooled fraction of <em>M. invisa</em> at 0.4 g/kg orally. Group III was administered with pooled fraction along with the decoction containing <em>H. auriculata, T. terrestris and B. diffusa</em> equivalent to 5 g/kg. The experiment was conducted for 20 days. Group II showed significant increase in biochemical parameters like alanine transaminase, aspartate transaminase, gamma glutamyl tranferase, creatine kinase, alkaline phosphatase, creatinine and urea, suggesting liver and kidney toxicity. Histopathological examination of the liver and kidney supported these findings. Heart also showed mild histopathological changes. Administration of decoction reversed the biochemical and histopathological changes, indicating the protective effect of decoction. ER -