TY - JOUR AU - Ezejiofor, Anthonet Ndidiamaka AU - Orisakwe, Orish Ebere PY - 2015/12/01 Y2 - 2024/03/29 TI - Asessment of the Hepatoprotective and Antioxidant Effect of Aqueous Leaf Extract of Costus after "Ker Gawl” on Cyclosporine a Induced Hepatotoxicity JF - Toxicology International JA - TI VL - 22 IS - 3 SE - Original Research DO - UR - https://www.informaticsjournals.com/index.php/toxi/article/view/20517 SP - 83-91 AB - <strong>Objective</strong>: <em>Costus afer</em> has long been used in traditional African setting in several instances though lack a prove of evidence for its numerous acclaimed potentials, however, this study is designed to investigate the hepatoprotective and antioxidant properties of aqueous leaf extract of <em>C. afer</em> against cyclosporine A (CsA) induced hepatotoxicity. <strong>Methods</strong>: Rats of similar weight were divided into six groups of five rats each. Groups 1 and 2 served as normal and toxic control received olive oil and 50 mg/kg CsA p.o., respectively. Groups 3, 4, 5, and 6 were given 375, 750, 1125 mg/kg p.o of the extract, and 100 mg/kg silymarin an hour prior to 50 mg/kg CsA, respectively, for 5 days. Physical, biochemical, and histological parameters estimated by reported methods serves as scientific evidence in the study. <strong>Results</strong>: <em>C. afer</em> significantly restored catalase (P &lt; 0.005), superoxide dismutase (P &lt; 0.005), malondialdehyde (P &lt; 0.005), and glutathione (P &lt; 0.05) levels dose dependently. In all cases as mentioned previously, <em>C. afer</em> at all dose level promoted significant (P &lt; 0.05) restoration of serum liver parameters such as aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, conjugated bilirubin, total bilirubin, total protein, and albumin. The biochemical observations were supplemented with histopathological reports, which showed attenuation of hepatocellular necrosis. <strong>Conclusion</strong>: Aqueous leaf extract of C<em>. afer</em> dose dependently prevented the significant changes on the physical, biochemical, and histological changes induced by CsA in the liver. Therefore, aqueous leaf extract of <em>C. afer</em> can be employed as an economic agent to treat liver diseases related to CsA administration and possibly other hepatotoxic drugs. ER -