TY - JOUR AU - Yadegari, Maryam AU - Khazaei, Mozafar AU - Mirhoseini, Mehri PY - 2015/12/01 Y2 - 2024/03/29 TI - Microscopical Evaluation of Healing Effect of Falcaria vulgaris Extract on Aspirin-Induced Gastric Ulcer in Rats JF - Toxicology International JA - TI VL - 22 IS - 3 SE - Original Research DO - UR - https://www.informaticsjournals.com/index.php/toxi/article/view/20509 SP - 29-35 AB - <strong>Objectives</strong>: Gastroprotective effects of herbal medicine were shown in numerous studies. <em>Falcaria vulgaris</em> (Ghazzayaghi) has traditionally been used for the treatment of stomach disorders in the Northwest of Iran. The present study was carried out to evaluate the microscopic healing effect of <em>F. vulgaris</em> extract on aspirin-induced gastric damage in rats. <strong>Materials and Methods</strong>: Thirty five young male rats were divided into five groups (7 rats/group). Control (group I) treated with 1 ml/kg distilled water. Four groups of animals had been exposed to starvation for 48 h and then received aspirin (200 mg/kg) in 1 ml carboxymethyl cellulose (CMC) 1% solvent for 3 days. Then, groups II-IV of rats were treated with 150 mg/kg extract (experimental group), 20 mg/kg omeprazole (reference group) and CMC solution (ulcer control group) by gavages for 14 days, respectively. The fifth group only received aspirin for 3 days. Three hours after last treatment rats were sacrificed and the stomachs were fixed in formalin (10%) and sections of 6 μ in diameter were prepared. Ulcer index, curative ratio, and morphological characteristics of the stomach were assessed using hematoxylin and eosin and Van Gieson staining. Data were analyzed using one-way ANOVA and <em>post hoc</em> Tukey test. <strong>Results</strong>: The results indicated that <em>F. vulgaris</em> extract significantly decreased the ulcer index (P &lt; 0.01), increased curative ratio, and enhanced the formation of collagen fibers compare to aspirin and omeprazole groups. <strong>Conclusions</strong>: Hydroalcoholic extract of <em>F. vulgaris</em> showed significant microscopic healing effect on the aspirin-induced gastric ulcer. ER -