@article{Mahmudul Hasan_Sabbir Hossain_Abdullah Taher_Rahman_2021, title={Evaluation of Analgesic, Antidiarrheal and Hypoglycemic Activities of <i>Wendlandia paniculata</i> (Roxb.) DC Leaves Extract using Mice Model}, volume={28}, url={https://www.informaticsjournals.com/index.php/toxi/article/view/26775}, DOI={10.18311/ti/2021/v28i2/26775}, abstractNote={The leaves of &lt;em&gt;Wendlandia paniculata&lt;/em&gt; (Roxb.) DC is a rare folk medicine among tribal people even though there is no scientific literature available regarding its pharmacological potentials. This study aimed to evaluate the effects of crude methanol extract of &lt;em&gt;W. paniculata&lt;/em&gt; (Roxb.) DC. Leaves in mice model. The &lt;em&gt;in vivo&lt;/em&gt; glucose-lowering capacity of methanolic crude extract was analyzed utilizing the well-known tail tipping method. The central and peripheral analgesic activity was evaluated using the ‘tail flick’ and writhing assay respectively. The anti-diarrheal activity was evaluated using the method of castor oil-induced diarrhea in mice. As a result, oral administration (400 mg/ kg) of the extract resulted significant (P&amp;lt;0.001) delay in response to pain and inhibition of acetic acid-induced writhing response. The results were comparable to the respective standards morphine (2 mg/kg) and diclofenac (50 mg/kg). Likewise, maximum reduction (p&amp;lt;0.05) of blood glucose (32.3%) was observed 180 min after oral intake(400 mg/kg) of the extract compared to the 47% of the standard glibenclamide. Moreover, a reduction of diarrheal feces was observed 45.83% (p&amp;lt;0.001) compared to standard loperamide 70.83%. The &lt;em&gt;in vivo&lt;/em&gt; bioassays confirmed that the crude methanol extract of leaves of&lt;em&gt; W. paniculata&lt;/em&gt; possesses significant analgesic (central, peripheral) and antidiarrheal activity with mild glucose-lowering activity. Isolation of bioactive compounds is needed to justify the molecule responsible for the activity.}, number={2}, journal={Toxicology International}, author={Mahmudul Hasan, Mohammad and Sabbir Hossain, Md. and Abdullah Taher, Mohammad and Rahman, Tauhidur}, year={2021}, month={May}, pages={155–163} }