@article{Kouadio_Lattanzio_Ouattara_Kouakou_Visconti_2018, title={Assessment of Mycotoxin Exposure in Cí´te d’Ivoire (Ivory Coast) Through Multi"‘Biomarker Analysis and Possible Correlation with Food Consumption Patterns}, volume={21}, url={https://www.informaticsjournals.com/index.php/toxi/article/view/21397}, abstractNote={<strong>Scope:</strong> The aim of the presented study was to investigate the mycotoxin exposure of Ivorian population related to the consumption patterns of maize, peanuts, millet, and cassava product (attiéké). <strong>Materials and Methods:</strong> Maize flour samples (n = 51) were purchased from all Abidjan local markets, in the south of Ivory Coast, and urine (n = 99) was collected during the same reference period (July–September 2011) from volunteers living in Abidjan and Daloa cities. Reversed"‘phase liquid chromatography coupled with electrospray ionization triple quadrupole mass spectrometry (LC"‘ESI"‘MS/MS) was used to analyze aflatoxins (AFB<sub>1</sub>, AFB<sub>2</sub>, AFG<sub>1</sub>, and AFG<sub>2</sub>), ochratoxin A (OTA), fumonisins (FB<sub>1</sub>, FB<sub>2</sub>), deoxynivalenol (DON), zearalenone (ZEA), and T"‘2 and HT"‘2 toxins in maize flour samples, and their relevant biomarkers (AFM<sub>1</sub>, DON, DON + de"‘epoxydeoxynivalenol (DOM"‘1), FB<sub>1</sub>, α"‘zearalenol (ZOL), β"‘ZOL, and OTA) in urine samples. <strong>Results:</strong> Critical maize contamination was observed by AFs occurrence (total AFs 4.5 – 330.0 μg/kg) while OTA was found in 13% of samples analyzed. AFM<sub>1</sub> was detected in 40% of urines samples (0.06 – 14.11 ng/ml), OTA in 37% (0.01 – 0.42 ng/ml), FB<sub>1</sub> in 27% (0.07 to 15.31 ng/ml) and, DON was found in 21% of samples at levels up to 10.0 ng/ml. The correlation coefficients (R<sup>2</sup>) obtained by plotting the percentage of biomarker occurrence (positive samples) versus the frequency of food consumption revealed maize, peanuts, millet and attiéké were strongly linked to AFB<sub>1</sub> and OTA exposure with values of R<sup>2</sup> ranged from 0.462 to 0.956. <strong>Conclusion:</strong> The present study provided data on mycotoxin risk in Ivory Coast, revealing a frequent co"‘exposure to the major mycotoxins such as AFs, OTA, and fumonisins, which appeared to be related to the frequency of peanuts, maize, millet and attiéké consumption.}, number={3}, journal={Toxicology International}, author={Kouadio, James Halbin and Lattanzio, Veronica M. T. and Ouattara, Djeneba and Kouakou, Brou and Visconti, Angelo}, year={2018}, month={Jun.}, pages={248–257} }