@article{Jyothi_Reddy_K. S._Kumar_Reddy_2018, title={A study on free radical-induced renal toxicity due to cyclophosphamide and its amelioration with N-acetyl cysteine}, volume={16}, url={https://www.informaticsjournals.com/index.php/toxi/article/view/20872}, abstractNote={A study was conducted to evaluate the protective effect of N-acetyl cysteine (NAC) against experimentally-induced renal toxicity due to cyclophosphamide (CYP) in rats. Three groups (2, 3 and 4) of female <em>Wistar Kyoto</em> rats with 6 animals in each group were administered with CYP @ 40 mg/kg bwt on 1<sup>st</sup>, 3<sup>rd</sup>, 5<sup>th</sup> and 7<sup>th</sup> day by intraperitoneal route. Group 2 remained as toxic control. Group 3 received NAC from 1<sup>st</sup> to 14<sup>th</sup> day @ 0.2% of feed and group 4 was treated with NAC from 8<sup>th</sup> to 14<sup>th</sup> day. Group 1 was maintained on basal diet for 14 days. The study revealed a significant (P < 0.05) increase in the concentration of serum creatinine, blood urea nitrogen, thiobarbituric acid reacting substances (TBARS) and protein carbonyls, and a decrease in the reduced glutathione (GSH) concentration of kidney. These results are suggestive of CYP-induced oxidative stress resulting in renal damage. Feeding of NAC could not offer protection against CYPinduced renal damage in this study.}, number={2}, journal={Toxicology International}, author={Jyothi, K. and Reddy, A. Gopala and K. S., Gopi and Kumar, B. Anil and Reddy, G. Dilip}, year={2018}, month={Apr.}, pages={137–139} }