Safety and Anti-Fatigue Activity of Ayurvedic Formulation Sramahara Mahaakaasaya - A Pre-Clinical Study

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Authors

  • Bidhan Mahajon
     Central Council for Research in Ayurvedic Sciences (CCRAS), Ministry of AYUSH, New Delhi - 110058 ,IN
  • A. Ramamurthy
     PG Department of Dravyaguna Vigyana, National Institute of Ayurveda, Jaipur - 302002, Rajasthan ,IN
  • Rupashri Nath
     Department of Roganidana and Vikritivigyana, Uttrakhand Ayurved University, Dehradun - 248001, Uttrakhand ,IN
  • Manish K. Gautam
     Assam down town University, Panikhaiti, Guwahati - 781026, Assam ,IN
  • Neeladri Das
     Molecular Endocrinology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand ,IN
  • Partha Roy
     Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand ,IN

DOI:

https://doi.org/10.18311/ti/2022/v29i4/30296

Keywords:

Acute Toxicity, Anti-Anxiety, Anti-Fatigue, Shramahara Mahaakashaaya.
Pre-clinical Pharmacology

Abstract

An experimental evaluation of anti-fatigue activity of Shramahara Mahaakashaaya (SM) and its applicability in sports medicine has been systematically evaluated. Aqueous, ethanolic and petroleum ether extracts of SM granules (200mg/kg) were studies for light-dark model test for assessment anti-anxiety effect, rota-rod test for assessment of the effect on muscle tone and muscle balance, weight loaded forced swimming test for assessment of anti-fatigue activity. The acute toxicity study of SM granules has also been evaluated as per the OECD 423. SM granules showed significant anti-fatigue activity in different experimental models and found safe up to 2000mg/kg body weight dose. The results provide an important basis for considering Shramahara Mahaakashaaya (SM) as an alternative medicine having anti-fatigue effects which can be further included in the sports medicine.

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Published

2023-02-07

How to Cite

Mahajon, B., Ramamurthy, A., Nath, R., Gautam, M. K., Das, N., & Roy, P. (2023). Safety and Anti-Fatigue Activity of Ayurvedic Formulation <i>Sramahara Mahaakaasaya</i> - A Pre-Clinical Study. Toxicology International, 29(4), 493–505. https://doi.org/10.18311/ti/2022/v29i4/30296

Issue

Volume 29, Issue 4, December 2022

Section

Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2022-05-18
Accepted 2022-06-23
Published 2023-02-07

 

References

Fu FH, Tjoumakaris FP, Buoncristiani A. Building a sports medicine team. Clinics in sports medicine. 2007:26(2):173-179. https://doi.org/10.1016/j.csm.2006.12.003 DOI: https://doi.org/10.1016/j.csm.2006.12.003

Dave P, Vyas H, Vyas M. A Pilot Study on Sports Medicine in Ayurveda wit Special Reference to Sarira Bala Vriddhi. AYU. 2007;28:32­37. https://www.ayujournal.org/article.asp?issn=0974-8520;year=2007;volume=28;issue=2; spage =32;epage=37;aulast=Dave;type=0

Mahajon B, Murthy AR. Relevance of Shramaharamahakashaya (An anti-fatigue formulation) in sports medicine. Journal of Scientific and Innovative Research. 2018; 7(1):15-17. http://www.jsirjournal.com/Vol7_Issue1_04.pdf DOI: https://doi.org/10.31254/jsir.2018.7104

Sir Monier Williams. Sanskrit-English dictionary, Mothilal Banarsidass publications Varanasi. 2005;1096p. https://www.mlbd.in/products/a-sanskrit-english-dictionary-etymologically-and-philologically-arranged-m-monier-williams-9788120831056-8120831055.

Acharya Yadavji Trikamji. Agnivesha, Charakasamhita, Chaukhamba Sanskrit Sansthan, Varanasi. 2009;34 p.

Jones JF, Nisenbaum R, Solomon L, Reyes M, Reeves WC. Chronic fatigue syndrome and other fatiguing illnesses in adolescents: a population-based study. Journal of Adolescent Health. 2004;35(1):34-40. https://doi.org/10.1016/j.jadohealth.2003.09.007 DOI: https://doi.org/10.1016/S1054-139X(03)00372-0

Mahajon B, Murthy AR. Applied Knowledge of ‘Shrama’ (Fatigue) in Sushruta Samhita. Journal of Ayurvedic and Herbal Medicine. 2018;4(2):76-78. http://www.ayurvedjournal.com/JAHM_201842_07.pdf DOI: https://doi.org/10.31254/jahm.2018.4207

Mahajon B, Murthy AR. A comprehensive analysis on shrama (fatigue) in Ancient transecript of charakasamhita. Global Journal for Research Analysis. 2017;6(6):346-347. https://doi.org/10.36106/gjra DOI: https://doi.org/10.36106/gjra

Jin HM, Wei P. Anti-fatigue properties of tartary buckwheat extracts in mice. International Journal of Molecular Sciences. 2011;12(8):4770-4780. https://doi.org/10.3390/ijms12084770 DOI: https://doi.org/10.3390/ijms12084770

Reilly T, Ekblom B. The use of recovery methods post?exercise. Journal of sports sciences. 2005;23(6):619-627. https://doi.org/10.1080/02640410400021302 DOI: https://doi.org/10.1080/02640410400021302

Rahman K. Studies on free radicals, antioxidants, and co-factors. Clinical interventions in aging. 2007;2(2):219. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684512/pdf/cia-2-219.pdf

OECD. 2001. Acute Oral Toxicity: Acute Toxic Class Method. Test Guideline 423. https://www.oecd-ilibrary.org/environment/test-no-423-acute-oral-toxicity-acute-toxic-class-method_9789264071001-en

Gautam MK, Singh A, Rao CV, Goel RK. Toxicological evaluation of Murraya paniculata (L.) leaves extract on rodents. The American Journal of Pharmacology and Toxicology. 2012;7(2):62–67. https://doi.org/10.3844/ajptsp.2012.62.67 DOI: https://doi.org/10.3844/ajptsp.2012.62.67

Gautam MK, Goel RK. Toxicological Study of Ocimum sanctum Linn Leaves: Hematological, Biochemical, and Histopathological Studies. Journal of Toxicology. 2014:Article ID 135654. https://doi.org/10.1155/2014/135654. DOI: https://doi.org/10.1155/2014/135654

Ford JL, Ildefonso K, Jones ML, Arvinen-Barrow M. Sport-related anxiety: current insights. Open access journal of sports medicine. 2017;8:205-212. https://doi.org/10.2147/OAJSM.S125845 DOI: https://doi.org/10.2147/OAJSM.S125845

Bourin M, Hascoët M. The mouse light/dark box test. European journal of pharmacology. 2003;463(1-3):55-65. https://doi.org/10.1016/s0014-2999(03)01274-3 DOI: https://doi.org/10.1016/S0014-2999(03)01274-3

Shimada T, Matsumoto K, Osanai M, Matsuda H, Terasawa K, Watanabe H. The modified light/dark transition test in mice: evaluation of classic and putative anxiolytic and anxiogenic drugs. General pharmacology. 1995;26(1):205-210. https://doi.org/10.1016/0306-3623(94)00148-g DOI: https://doi.org/10.1016/0306-3623(94)00148-G

Shiotsuki H, Yoshimi K, Shimo Y, Funayama M, Takamatsu Y, Ikeda K, Takahashi R, Kitazawa S, Hattori N. A rotarod test for evaluation of motor skill learning. Journal of neuroscience methods. 2010;189(2):180-185. https://doi.org/10.1016/j.jneumeth.2010.03.026 DOI: https://doi.org/10.1016/j.jneumeth.2010.03.026

Can A, Dao DT, Arad M, Terrillion CE, Piantadosi SC, Gould TD. The mouse forced swim test. Journal of Visualized Experiments. 2012;59:e3638. https://doi.org/10.3791/3638 DOI: https://doi.org/10.3791/3638-v

Coyle EF. Substrate utilization during exercise in active people. The American journal of clinical nutrition. 1995;61(4):968S-979S. https://doi.org/10.1093/ajcn/61.4.968S DOI: https://doi.org/10.1093/ajcn/61.4.968S

Wang B, Yan F, Cai L. Anti-fatigue properties of icariin from Epimedium brevicornum. Biomedical Research. 2014;25(3):297-302. https://www.alliedacademies.org/articles/antifatigue-properties-of-icariin-from-epimedium-brevicornum.html

Hody S, Rogister B, Leprince P, Wang F, Croisier JL. Muscle fatigue experienced during maximal eccentric exercise is predictive of the plasma creatine kinase (CK) response. Scandinavian journal of medicine & science in sports. 2013;23(4):501-507. https://doi.org/10.1111/j.1600-0838.2011.01413.x DOI: https://doi.org/10.1111/j.1600-0838.2011.01413.x

Dahlstedt AJ, Katz A, Wieringa BE, Westerblad H. Is creatine kinase responsible for fatigue? Studies of isolated skeletal muscle deficient in creatine kinase. The FASEB Journal. 2000;14(7):982-990. https://doi.org/10.1096/fasebj.14.7.982 DOI: https://doi.org/10.1096/fasebj.14.7.982

Wasserman K. Coupling of external to cellular respiration during exercise: the wisdom of the body revisited. American Journal of Physiology-Endocrinology and Metabolism. 1994;266(4):E519-E539. https://doi.org/10.1152/ajpendo.1994.266.4.E519 PMid:8178973 DOI: https://doi.org/10.1152/ajpendo.1994.266.4.E519

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