In Silico Studies and Histopathological Analysis on the Bioremediation Effect of Spirulina in Various Tissues of Diclofenac Treated Pangasius Sps

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Authors

  • K. S. Shreenidhi
     Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu ,IN
  • Saranya Sri Santhanam
     Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu ,IN
  • Shreaya Bhaskar
     Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu ,IN
  • Sowmia Narayan Sridhar
     Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu ,IN
  • B. Vijaya Geetha
     Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu ,IN

DOI:

https://doi.org/10.18311/ti/2021/v28i3/27327

Keywords:

Diseases, Remediation, Spirulina, Toxicity
Ecotoxicology

Abstract

The aquatic biome is an integral part of Earth's survival. Humans, with an attitude to lead a comfortable life, have invaded the ecosystem to a larger extent owing to many direct and indirect catastrophes in the longer run. Our aim was to establish the link between the genes and compounds that turn toxic to the organisms over due course of time. With the selected compound as diclofenac, Comparative Toxicogenomics database was used to identify the diseases related to the compounds, the top expressing genes, and the common genes of the compounds. By incorporating the coalescence of spirulina bioremediation under histopathological studies, the effect of the algae was observed. From these two studies, we were able to conclude that there was a significant link between the effects of the compound on the organisms.

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Published

2021-08-23

How to Cite

Shreenidhi, K. S., Sri Santhanam, S., Bhaskar, S., Narayan Sridhar, S., & Vijaya Geetha, B. (2021). <i>In Silico</i> Studies and Histopathological Analysis on the Bioremediation Effect of Spirulina in Various Tissues of Diclofenac Treated <i>Pangasius</i> Sps. Toxicology International, 28(3), 239–244. https://doi.org/10.18311/ti/2021/v28i3/27327

Issue

Volume 28, Issue 3, July-September 2021

Section

Original Research
Crossref
Scopus
Google Scholar
Europe PMC
Received 2021-03-15
Accepted 2021-05-23
Published 2021-08-23

 

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