Rutin a Citrus Flavonoid Attenuates Sodium Arsenate Induced Cytotoxicity in CHO Cells


  • Department of Biotechnology, MIT, MAHE, Manipal – 576104, Karnataka
  • Department of Chemistry, MIT, MAHE, Manipal – 576104, Karnataka
  • Department of Biochemistry, KMC, MAHE, Manipal – 576104, Karnataka



CHO, GSH, GST, SOD, Sodium Arsenate


The potential role of oxidative stress in the pathogenesis induced by arsenic proposes that antioxidants can be deliberated as an alternative approach in alleviating arsenic-induced toxicity. The aim of this work was to assay in vitro the potential advantageous effects of plant flavonoid rutin against arsenate exposure, by studying lipid peroxidation and the stress-related markers. Rutin, a flavanol, has been exhibiting anti-cancer property, mitigating, hostile to diabetic and anti-inflammatory properties. CHO cells were selected to study the effect of sodiumarsenate and its amelioration by rutin a citrus flavonoid glycoside. Sodium arsenate at low concentration induced cytotoxicity and genotoxicity. MTT assay, Catalase, Superoxide dismutase, GSH, GST and lipid peroxidation was measured in CHO cell. Pre-treatment of CHO cells with rutin attenuated arsenate induced toxicity. DNA damage was also measured.


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How to Cite

Salmataj, S. A., Bhat, P., & Kamath, S. (2022). Rutin a Citrus Flavonoid Attenuates Sodium Arsenate Induced Cytotoxicity in CHO Cells. Toxicology International, 27(3&4), 188–192.



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