Malignant Hyperthermia in Endosulfan Poisoning

Authors

Keywords:

Endosulfan, malignant hyperthermia, poisoning, seizure

Abstract

We are reporting a case of endosulfan poisoning, admitted in a state of altered consciousness, vomiting, and seizure. The diagnosis was based on history, physical examination and positive reports from toxicological screening. After 8 hrs of admission, a sudden rise in EtCO2, respiratory rate, heart rate, blood pressure, and body temperature was noted. Masseter spasm was there and patient's elbow/knees could not be bent upon manipulation. Caffeine halothane contraction test later confirmed it to be malignant hyperthermia (MH). We suggest that if there is a sudden rise in body temperature, stiffness in limbs or massater spasm in a case of endosulfan poisoning, the diagnosis of MH should be considered as one possibility when etiology is not certain.

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References

Piatkowski A, Gröger A, Bozkurta A, Fuchsa PC, Palluaa N. Acetone associated inhalation injury and rhabdomyolysis. Burns 2007;33:932-4.

Klaassen CD, Watkins JB. Casarett and Doull's toxicology: The basic science of poisons. 5th ed. New York: MacGraw-Hill Publishing Company; 1999. p. 542-7.

Excitable tissue: muscle. In: Ganong WF editor. Review of medical physiology. 20th ed. New York: McGraw Hill Companies, Inc.; 2001. p. 67.

Dorval J, Hontela A. Role of glutathione redox cycle and catalase in defense against oxidative stress induced by endosulfan in adrenocortical cells of rainbow trout (Oncorhynchus mykiss). Toxicol Appl Pharmacol 2003;192:191-200.

Karatas AD, Aygun D, Baydin A. Characteristics of endosulfan poisoning: a study of 23 cases Singapore Med J 2006;47:1030-2.

Published

2018-08-21

How to Cite

Jain, G., Singh, D. K., & Yadav, G. (2018). Malignant Hyperthermia in Endosulfan Poisoning. Toxicology International, 19(1), 74–76. Retrieved from https://www.informaticsjournals.com/index.php/toxi/article/view/21849

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