Environmental Risks of Insecticides Cholinesterase Inhibitors


Affiliations

  • Emergency Hospital, Mansoura University, Toxicology Unit, Egypt

Abstract

This study conducted on 423 inhabitant (372 adults and 51 children) blood samples were collected from patients hosted in the Emergency Hospital of Mansoura University. The clinical diagnosis of such patients was acute insecticides poisoning. The aim of the present study is to study patients with cholinesterase (ChE) inhibitor organophosphorus insecticides intoxication from the laboratory point of view. The plasma samples were analyzed for levels of ChE enzyme and acetyl cholinesterase enzyme activity by spectrophotometer. The pesticides were identified using Gas Chromatography‑Electron Captured Detector (GC‑ECD). The results of GC‑ECD instrument of all patients revealed that parathion (organophosphorous insecticide) poisoning was found in their blood samples. The mode of poisoning was accidentally by inhalation and skin contact. The poisoning cases of children were of mild poisoning. The degrees of poisoning of adults were severe in 138, moderate in 201 and mild in 33 cases. In conclusion, results of the present study revealed that the widely used insecticides in Dakahlyia governorate are the organophosphorous insecticides specifically parathion insecticide.

Keywords

Cholinesterase, chromatography, organophosphorous, spectrometry

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