Cold Stress Offered Modulation on Chlorpyrifos Toxicity in Aging Rat Central Nervous System

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Authors

  • Mahaboob Basha
     Department of Zoology, Bangalore University, Bangalore, Karnataka ,IN
  • Annappa Poojary
     Government College for Boys, Kolar, Karnataka ,IN

Keywords:

Acetylcholinesterase, ATPases, ChAT, chlorpyrifos, CNS, cold stress, interactive effects
Zoography

Abstract

The adverse effects produced by chlorpyrifos (CPF) or cold stress alone in humans and animals are well documented, but there is no information available relating to the consequences of their co- exposure in an age-related manner. In this study, effects of sublethal doses of CPF were carried out in vivo, for 48 h to assess the biochemical perturbations in relation to interactions with cold stress (15°C and 20°C) in different age group rat CNS. A positive interaction of CPF with age of animal and cold exposure was observed resulting in marked decrease in the activity levels of AChE (P<0.05), ChAT (P<0.05), Na+, K+-ATPase (P<0.05), Ca2+-ATPase (P<0.05), and Mg2+-ATPase (P<0.05). The ANOVA and posthoc analysis showed that regulatory enzymes decreased significantly (P<0.05) on CPF exposure. Overall, the effect of co-exposure was appreciably different from either of the exposures. Synergistic interaction of CPF and cold stress at 15°C showed higher inhibition in comparison with CPF and cold stress alone and together at 20°C. Further, this study reveals that young animals are significantly vulnerable and sensitive than adults.

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Published

2018-05-25

How to Cite

Basha, M., & Poojary, A. (2018). Cold Stress Offered Modulation on Chlorpyrifos Toxicity in Aging Rat Central Nervous System. Toxicology International, 19(2), 173–181. Retrieved from https://www.informaticsjournals.com/index.php/toxi/article/view/21362

Issue

Volume 19, Issue 2, May-August 2012

Section

Original Research
Received 2018-05-24
Accepted 2018-05-24
Published 2018-05-25

 

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