Hematoxicity of Amodiaquine in Sprague-Dawley Rats

Authors

  • Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State
  • Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State
  • Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State
  • Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State

Keywords:

Amodiaquine, hematological parameters, malaria, toxicity

Abstract

Objective: The use of amodiaquine (AQ) and its associated toxic effect has been a major public health concern since cases of life-threatening agranulocytosis and hepatic toxicity were reported during its prophylactic use. The objective of this study was to evaluate the hematological safety profile of AQ therapy. Materials and Methods: Sprague-Dawley rats were randomly distributed into four groups (n=5). Group 1 was the control, while groups 2, 3, and 4 received AQ treatment for 14 days at varying doses of 5 mg/kgBW, 10 mg/kgBW, and 15 mg/kgBW daily, respectively. Results: Following treatment, hematological variables were comparable in all groups (P>0.05). Conclusion: This study provides evidence to support the use of AQ in the treatment of uncomplicated malaria. However, to prevent emergence of local drug resistance, it should be used as part of a combination therapy. Monitoring for adverse effects is suggested.

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Published

2018-05-25

How to Cite

Saka, W. A., Akhigbe, R. E., Akinola, A. O., & Azeez, O. M. (2018). Hematoxicity of Amodiaquine in Sprague-Dawley Rats. Toxicology International, 19(2), 112–114. Retrieved from https://www.informaticsjournals.com/index.php/toxi/article/view/21350

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Original Research

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