Ameliorative Effects of Tinospora Cordifolia Root Extract on Histopathological and Biochemical Changes Induced by Aflatoxin-B1 in Mice Kidney

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Authors

  • Rekha Gupta
     Department of Bioscience and Biotechnology, Banasthali University, Banasthali-304022, Rajasthan ,IN
  • Veena Sharma
     Department of Bioscience and Biotechnology, Banasthali University, Banasthali-304022, Rajasthan ,IN

Keywords:

Aflatoxin, antioxidant, mice, oxidative stress, Tinospora cordifolia
Phylogeography

Abstract

The present study was planned to investigate the ability of the Tinospora cordifolia to scavenge free radicals generated during aflatoxicosis. A total no. of 48 male Swiss albino mice (30 ± 5 g) were exposed to Aflatoxin B1 (AFB1) (2 μg/30 g b.wt, orally) either individually or in combination with T. cordifolia (50, 100, 200 mg/kg, orally) once daily for 25 days. AFB1 exposure led to significant rise in thiobarbituric acid reactive substances (TBARS) and fall in superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR), ascorbic acid, and protein content. T. cordifolia was found to show protective effect by lowering down the content of TBARS and enhancing the GSH, ascorbic acid, protein, and the activities of antioxidant enzymes viz., SOD, CAT, glutathione peroxidase, GST, and GR in kidney. Histopathological analysis of kidney samples also confirmed the protective values and antioxidant activity of ethanolic extract of herb. T. cordifolia showed protection against aflatoxin-induced nephrotoxicity due to the presence of alkaloids such as a choline, tinosporin, isocolumbin, palmatine, tetrahydropalmatine, and magnoflorine.

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Published

2018-05-18

How to Cite

Gupta, R., & Sharma, V. (2018). Ameliorative Effects of <i>Tinospora Cordifolia</i> Root Extract on Histopathological and Biochemical Changes Induced by Aflatoxin-B<sub>1</sub> in Mice Kidney. Toxicology International, 18(2), 94–98. Retrieved from https://www.informaticsjournals.com/index.php/toxi/article/view/21250

Issue

Volume 18, Issue 2, July-December 2011

Section

Articles
Received 2018-05-17
Accepted 2018-05-17
Published 2018-05-18

 

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