Embryotoxic and teratogenic evaluation of cyfluthrin in Swiss albino mice


  • Department of Zoology, Environmental Toxicology Laboratory, Centre for Advanced Studies, University of Rajasthan, Jaipur-302004
  • Department of Zoology, Environmental Toxicology Laboratory, Centre for Advanced Studies, University of Rajasthan, Jaipur-302004
  • Department of Zoology, Environmental Toxicology Laboratory, Centre for Advanced Studies, University of Rajasthan, Jaipur-302004
  • Department of Zoology, Environmental Toxicology Laboratory, Centre for Advanced Studies, University of Rajasthan, Jaipur-302004


Cyfluthrin, embryotoxicity, mice, teratogenecity


Pesticides are known for their toxicity on the mammalian systems including the embryonal development. Cyfluthrin (trade name: Baygon, Solfac) is used commonly in almost every household in India. It is reported to be neurotoxic, hepatotoxic and haematotoxic in rats and to cause miscarriages and resorptions in pregnant rabbits. It was therefore planned to assess its teratogenic potential in Swiss albino mice. Pregnant dams were orally administered two doses of the insecticide (16 mg/kg and 32 mg/kg body weight) during the organogenetic phase i.e. days 5-14 of gestation. There occurred a dose related decrease in the weight gained by the females during the gestation period. The higher dose affected the litter size, number of live fetuses, resorptions and the average fetal weight significantly. The fetal anomalies observed were reduced ossification of the skull bones and phalanges and widened cranial sutures.


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Adams, KJ, Chavasse, DC, Mount, DL, Carneiro, IA and Curtis, CF (2002). Comparative insecticidal power of three pyrethroids on netting. Med. Vet. Entomol., 16: 106–108.

Andrews, JE and Gray, EL (1990). The effects of lindane on calcium metabolism, bone morphometry and the kidney in rats. Toxicol., 60: 99-197.

Bhatnagar, P and Soni, I (1988). Evaluation of the teratogenic potential of phosphamidon in mice by gavage. Toxicol. Letters, 42: 101-107.

Cremlyn, RJ (1991). Agrochemicals: Preparation and mode of action. Chichester,U.K.: John Wiley & Sons. pp. 68-69.

Dave, JM (1985). The Bhopal methyl isocyanate (MIC) incident. An overview. In Proc. Int. Symp. Highly Toxic Chemical Detection and protection methods, ed. H.B. Schiefer, pp 1-38. Saskatoon, Sasketchewan; University of Saskatoon.

Dawson, AB (1927). A note on the staining of skeleton of cleared specimens with Alizarin red S. stain. Technol., 1: 123-124.

Dhar, B, Soni, I and Bhatnagar, P (2004). Assessment of teratogenic potential of fenpropathrin, a synthetic pyrethroid insecticide, in Swiss albino mice. J. Ecophysiol. Occup. Hlth., 4: 185-189.

Farag, AT, El- Okazy, AM and El-Aswed, AF (2003). Developmental toxicity of chlorpyrifos in rats. Reproductive Toxicol., 17: 203-208.

Farag, AT, Karkour, TA and Okazy, AE (2006). Developmental toxicity of orally administered technical dimethoate in rats. Reprod. Toxicol. 77(1): 40-46.

Freeman, N, Shalat, S, Black, K, Jimenez, M, Donnelly, K and Calvin, A (2004). Seasonal pesticide use in a rural community on the US/Mexico border. J. Expo. Anal. Environ. Epidemiol., 14: 473–478.

Giavini, E, Vismara, C and Broccia, ML (1982). Pre and postimplantation embryotoxic effects of zinc-dimethyldithiocarbamate (Ziram) in the rat. Ecotoxicol. Environ. Safety, 7: 531-537.

Hoogenboom, ER, Ransdell, JF, Ellis, WG, Kavlock, RJ and Zeman, FJ (1991). Effects on the fetal rat eye of maternal benomyl exposure and protein malnutrition. Curr. Eye Res., 10: 601-612.

Iyer, P, Gammon, D, Gee, J and Pfeifer, K (1999). Characterization of maternal influence on teratogenicity: an assessment of developmental toxicity studies for the herbicide cyanazine. Regul. Toxicol. Pharmacol., 29(1): 88-95.

Kavlock, RJ, Chernoff, N, Hanisch, RC, Gray, J, Rogers, E and Gray, LE Jr. (1981). Perinatal toxicity of endrin in rodents II. Fetotoxic effects of prenatal exposure in rats and mice. Toxicol., 21: 141-150.

Kavlock, RJ, Chernoff, N, Gray, LF, Gray, JA Jr. and Whitehouse, D (1982). Teratogenic effects of benomyl in the Wistar rats and CD-1 mouse, with emphasis on the route of administration. Toxicol. Appl. Pharmacol., 62: 44-54.

Khera, KS (1974). Teratogenecity and dominant lethal studies on hexachlorobenzene in rats. Food Cosmet. Toxicol., 12: 471-477.

Marwick, C (1985). Bhopal tragedy's repercussions may reach American physicians. J. Am. Med. Assoc., 253: 2001-2013.

Mathur, A and Bhatnagar, P (1991). A teratogenic study of carbaryl in Swiss albino mice. Fd. Chem. Toxicol., 29(9): 629-632.

Murray, FJ, Staples, RE and Schwetz, BA (1979). Teratogenic potential of carbaryl given to rabbits and mice by gavage or by dietary inclusion. Toxicol. Appl. Pharmacol., 51: 81-89.

Narotsky, MG and Kavlock, RJ (1995). A multidisciplinary approach to toxicological screening: II. Developmental toxicity. J. Toxicol. and Environ. Hlth., 45: 145–171.

Ozeki, H and Shirai, S (1998). Developmental eye abnormalities in mouse fetuses induced by retinoic acid. Japan. J. Ophthalmol., 42(3): 162-167.

Purkerson-Parker, S, McDaniel, KL and Moser, VC (2001). Dopamine transporter binding in the rat striatum is increased by gestational, perinatal, and adolescent exposure to heptachlor. Toxicol. Sci., 64(2): 216–223.

Roberts, T and Hutson, D eds. (1999). Metabolic Pathways of Agrochemicals, Part 2. Insecticides and Fungicides. Cambridge, UK: Royal Society of Chemistry.

Sakata-Haga, H, Sawada, K, Ohnishi, T and Fukui, Y (2004). Hydrocephalus following prenatal exposure to ethanol. Acta Neuropathol., 108(5): 393-398.

Schimmel, SC (1983). Acute toxicity, bioconcentration, and persistence of AC 222705, benthiocarb, chlorpyrifos, fenvalerate, methyl parathion and permethrin in the estuarine environment. J. Agric. Food Chem., 31(2): 399-407.

Sitarek, K (2004). Teratogenic effects of rubber components. Med. Pr., 55(1): 93-99.

Stevens, MA, Fitzgerald, S, Menache, MG, Costa, DL and Bucher, JR (1987). Functional evidence of persistent airway obstruction in rats following a two- hour inhalation exposure to methyl isocyanate. Environ. Hlth. Perspect., 72: 89-94.

Thompson, WT (1992). Agricultural chemicals Handbook, Book 1. Thompson Publication. Fresne. CA.

Tian, Y, Ishikawa, H, Yamaguchi, T, Yamauchi, T, Yokoyama, K (2005). Teratogenicity and developmental toxicity of chlorpyrifos. Maternal exposure during organogenesis in mice. Reprod. Toxicol., 20(2): 267-270.

US EPA. Office of Pesticide Programs. (1989). "Tox oneliners”. Cyfluthrin. Washington, DC (June 28).

Welsch, F and Morgan, KT (1985). Placental transfer and developmental toxicity of 2,2',4,4', 5,5' hexabromobiphenyl in B6C3F1 mice. Toxicol. Appl. Pharmacol., 81: 431-442.

Wilson, JG (1965). Embryological considerations in teratology. In J.G. Wilson and J.K. Warkany (Eds), Teratology: Principles and Techniques. University of Chicago Press, Chicago, IL pp. 251-261.



How to Cite

Syed, F., Soni, I., John, P. J., & Bhatnagar, P. (2018). Embryotoxic and teratogenic evaluation of cyfluthrin in Swiss albino mice. Toxicology International, 16(2), 121–126. Retrieved from https://www.informaticsjournals.com/index.php/toxi/article/view/20869



Original Research