Oxidative stress due to ochratoxin and T-2 toxin either alone or in combination and evaluation of protective role of <i>Curcuma longa, Zingiber officinale</i>, toxichek and activated charcoal

Authors

  • Usha Rani M. Department of Pharmacology & Toxicology, College of Veterinary Science, Hyderabad-500030
  • Gopala Reddy A. Department of Pharmacology & Toxicology, College of Veterinary Science, Hyderabad-500030
  • Dilip Reddy G. Department of Pharmacology & Toxicology, College of Veterinary Science, Hyderabad-500030
  • Alpha Raj M. Assistant professor, Dept. of Pharmacology & Toxicology, College of Veterinary Science, Tirupati -517 502

Keywords:

Activated charcoal (AC), ochratoxin (OTA), trichothecene (T-2)

Abstract

A study was conducted on poultry to evaluate the oxidative stress due to ochratoxin and T-2 either alone or in combination. Broiler chicks were fed OTA @2ppm,T-2 @ 1ppm, Zingiber officinale (rhizome shade dried and powdered @ 0.5%, Curcuma longa rhizome @ 0.5%, toxichek @ 0.1% and activated charcoal @ 0.4% in feed in combinations of 20 groups. The study revealed a significant (p<0.05) increase in the activities of glutathione peroxidase, glutathione reductase, catalase and TBARS in toxic groups (OTA, T-2 and OTA+T-2). Results of the present study suggest that OTA and T-2 either alone or in combination induce oxidative stress and supplementation of Curcuma longa, Zingiber officinale, toxichek and activated charcoal in order showed amelioration by stabilizing the antioxidant defenses.

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Published

2018-04-05

How to Cite

M., U. R., A., G. R., G., D. R., & M., A. R. (2018). Oxidative stress due to ochratoxin and T-2 toxin either alone or in combination and evaluation of protective role of <i>Curcuma longa, Zingiber officinale</i>, toxichek and activated charcoal. Toxicology International, 16(1), 63–68. Retrieved from https://www.informaticsjournals.com/index.php/toxi/article/view/20847

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Section

Original Research