Bilateral Eyelid Ptosis, Attributed to Vincristine, Treated Successfully with Pyridoxine and Thiamine in a Child with Acute Lymphoblastic Leukemia

Authors

  • Emmanuel Hatzipantelis
     Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, AHEPA General Hospital, Thessaloniki
  • Ioannis Kyriakidis
     Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, AHEPA General Hospital, Thessaloniki
  • Evangelos Pavlou
     Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, AHEPA General Hospital, Thessaloniki
  • Efterpi Pavlidou
     Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, AHEPA General Hospital, Thessaloniki

Keywords:

Neurotoxicity, Ptosis, Vincristine, Vitamin B1, Vitamin B6.

Abstract

Vincristine-induced neurotoxicity is an adverse effect commonly seen in pediatric patients treated for cancer. We hereby present a case of a 6-year-old boy with acute lymphoblastic leukemia, who developed bilateral eyelid ptosis 25 days after the last intravenous administration of vincristine (cumulative dose 14.2 mg i.e., 17.75 mg/m²). The boy was treated with 5 mg/kg thiamine and with 10 mg/kg pyridoxine. Complete recovery of ptosis was noticed 4 weeks after the initiation of Vitamins B1 and B6 supplementation therapy.

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Published

2015-04-01

How to Cite

Hatzipantelis, E., Kyriakidis, I., Pavlou, E., & Pavlidou, E. (2015). Bilateral Eyelid Ptosis, Attributed to Vincristine, Treated Successfully with Pyridoxine and Thiamine in a Child with Acute Lymphoblastic Leukemia. Toxicology International, 22(1), 162–164. Retrieved from https://www.informaticsjournals.com/index.php/toxi/article/view/20330

Issue

Volume 22, Issue 1, January-April 2015

Section

Case Report