Surface Properties of Amphiphilic Drugs in Presence of Cationic Surfactants


  • Pt. Ravishankar Shukla University, School of Studies in Chemistry, Raipur, C.G., 492 010, India
  • Birla Institute of Technology and Science, Department of Chemistry, Pilani, Rajasthan, 333 031, India


Surface properties of two amphiphilic drugs i.e. amitriptyline and imipramine have been studied in the absence and presence of some cationic surfactants i.e. alkyltriphenylphosphonium bromide [R = 16 (CTPB), R = 14 (TTPB)] and alkyldiethylcthanolammonium bromide [R = 16 (CDEEAB), R = 14 (TDEEAB)] by surface tension measurement at 300 K. The critical micelle concentration (CMC), maximum surface excess concentration at the air/water interface (Γmax), minimum area per surfactant molecule at the air-water interface (Amin) and the surface pressure at the CMC (πCMC) have been determined. Γmax value increases and CMC/πCMC decrease & with an increasing mole fraction of surfactants. The solubility of amphiphilic drugs in cationic surfactant systems has also been studied.


Amphiphilic Drug, Additives, Cationic Surfactant, Surface Properties, Surface Tension.

Subject Discipline

Pharmacy and Pharmacology

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