TY - JOUR AU - Singh, Shriti AU - Gehlot, Sangeeta AU - Agrawal, N. K. PY - 2019/09/18 Y2 - 2024/03/29 TI - Basis of Disease Manifestation: A Molecular and Ayurvedic Approach with an Integrated Concept of Ayurgenomics JF - Journal of Natural Remedies JA - JNR VL - 19 IS - 3 SE - Review Articles DO - 10.18311/jnr/2019/23331 UR - https://www.informaticsjournals.com/index.php/jnr/article/view/23331 SP - 99-113 AB - <em>Ayurveda</em> and contemporary science comprehends human body as model to understand disease state from very different perspective hence their methodology to describe disease manifestation also seems very different as they observe same problem from different viewpoints. For more precision in healthcare system it is essential that best of both systems need to be integrated, In <em>Ayurvedic</em> texts, the description of concept of basic constitution/<em>Prakriti</em> in health and disease states is well described. The scripts are not clearly understandable and hence its importance has not been properly understood by contemporary biological researchers and thus not utilized. According to <em>Ayurveda</em> individual's basic constitution (<em>Prakriti</em>) influences and directs one's disease status, its treatment &amp; lifestyle regimen. In genomics, individual's basic constitution is decided by its genetic makeup. The current trend in <em>Ayurveda</em>-related biomolecular studies is establishment of high correlation between <em>Prakriti</em> and Genomics. This approach of Ayurgenomics would facilitate the development of alternative methods for cost effective screening of predisposed individuals in the population. This would result in development of an integrated approach to systems biology for disease and health state. For the establishment and success of this concept the prerequisite is integration of <em>Ayurveda</em> into mainstream contemporary biology to achieve global acceptability for the concepts and science of <em>Ayurveda</em>, and for this <em>Ayurvedic</em> concept based phenotypic (<em>Prakriti</em>) assessment needs to be made so that difference among individuals from large population based on their physical, physiological and psychological status can be observed and they can be categorized by their specific predominant <em>Prakriti</em> i.e. <em>Vata, Pitta, Kapha</em>. Information about individual predominant <em>Prakriti</em> can be further analyzed on certain genomic parameters related to gene expression, genetic, epigenetic and biochemical factors, which can be further utilized for Integration of <em>Ayurveda</em> with Genomics for systems biology approach in predictive and personalized medicine. ER -