Ulam Herbs of Oenanthe javanica and Cosmos caudatus: an overview on their Medicinal Properties

Jump To References Section

Authors

  • Faculty of Applied Sciences, UCSI University, Cheras - 56000, Kuala Lumpur ,MY
  • School of Science, Monash University Sunway, Petaling Jaya - 46150, Selangor ,MY
  • International Society for Mangrove Ecosystems, Faculty of Agriculture, University of the Ryukyus, Okinawa 903-0129 ,JP

DOI:

https://doi.org/10.18311/jnr/2016/8370

Keywords:

Pharmacology, Phytochemistry, Toxicity, Water Dropwort, Wild Cosmos
Pharmacognosy

Abstract

In Southeast Asia, ulam herbs are consumed raw as a condiment. It is believed that these herbs have medicinal benefits and their regular intake can prevent degenerative diseases, delay aging and improve overall health. In this review, the current knowledge on the phytochemistry and pharmacology of Oenanthe javanica (water dropwort) and Cosmos caudatus (wild cosmos) is updated with some descriptions of their botany and uses. Water dropwort has constituents of phenylpropanoids, flavonoids and phenolic acids, notably, persicarin and isorhamnetin. Antioxidant, anti-quorum sensing, melanogenic, anti-diabetic, anti-arrhythmic, anti-inflammatory, neuroprotective, neurogenesis, alcohol detoxification, antitoxic, anti-coagulant, hepatoprotective, anti-hepatitis B virus and memory improvement are pharmacological properties of water dropwort. Wild cosmos, with flavonoids, phenolic acids and diterpenoids as major metabolites, possesses antioxidant, antibacterial, anti-quorum sensing, antifungal, anti-inflammatory, anti-diabetic, anti-hypertensive, hepatoprotective, detoxification, anti-osteoporosis and anti-hyperlipidemic activities. There are several patents on some of the pharmacological properties of water dropwort while a clinical trial has been conducted on the anti-diabetic effects of wild cosmos. Both these ulam herbs possess a wide array of pharmacological properties, which confer their traditional uses as food and medicine.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Downloads

Published

2017-04-07

How to Cite

Chan, E. W. C., Wong, S. K., & Chan, H. T. (2017). Ulam Herbs of <I>Oenanthe javanica</I> and <I>Cosmos caudatus</I>: an overview on their Medicinal Properties. Journal of Natural Remedies, 16(4), 137–147. https://doi.org/10.18311/jnr/2016/8370

Issue

Section

Articles
Received 2016-10-17
Accepted 2016-12-01
Published 2017-04-07

 

References

Reihani SFS, Azhar ME. Antioxidant activity and total phenolic content in aqueous extracts of selected traditional Malay salads (ulam). Int Food Res J. 2012; 19:1439–44.

Bunawan H, Baharum SN, Bunawan SN, Amin NM, Noor NM. Cosmos caudatus Kunth: A traditional medicinal herb. Global J Pharmacol. 2014; 8:420–6.

Cheng SH, Barakatun-Nisak MY, Anthony J, Ismail A. Potential medicinal benefits of Cosmos caudatus (ulam raja): a scoping review. J Res Med Sci. 2015; 20:1000–6.

Sasmitamihardja D. Oenanthe javanica (Blume) DC. In: Siemonsma JS, Piluek K, editors. Plant resources of SouthEast Asia No. 8: Vegetables. Leiden: Backhuys Publisher; 1993. p. 220–2.

Kim JY, Kim KH, Lee YJ, Lee SH, Park JC, Nam DH. Oenanthe javanica extract accelerates ethanol metabolism in ethanol-treated animals. BMB Rep. 2009; 42:482–5.

Park JC, Yu YB, Lee JH. Isolation of steroids and flavonoids from the herb of Oenanthe javanica DC. Korean J Pharmacogn. 1993; 24:244–6.

Fujita T, Kadoya Y, Aota H, Nakayama M. A new phenylpropanoid glucoside and other constituents of Oenanthe javanica. Biosci Biotechnol Biochem. 1995; 59:526–8.

Park JC, Young HS, Yu YB, Lee JH. Isorhamnetin sulphate from the leaves and stems of Oenanthe javanica in Korea. Planta Med. 1995; 61:377–8.

Cho HW, Lee SH, Nam DH, Kim JY, Lim SK, Lee JS, et al. Antioxidant activity and phytochemical study on the aerial parts of Oenanthe javanica. Korean J Pharmacogn. 2008; 39:142–5.

Ma CJ, Lee KY, Jeong EJ, Kim SH, Park J, Choi YH, et al. Persicarin from water dropwort (Oenanthe javanica) protects primary cultured rat cortical cells from glutamateinduced neurotoxicity. Phytother Res. 2010; 24:913–8.

Hwang SJ, Park SJ, Kim JD. Component analysis and antioxidant activity of Oenanthe javanica extracts. Korean J Food Sci Technol. 2013; 45:227–34.

Ogita T, Manaois RV, Wakagi M, Oki T, Ishikawa YT, Watanabe J. Identification and evaluation of antioxidants in Japanese parsley. Int J Food Sci Nutr. 2016; 67:431–40.

Pattiram PD, Lasekan O, Tan CP, Zaidul ISM. Identification of the aroma-active constituents of the essential oils of water dropwort (Oenanthe javanica) and kacip fatimah (Labisia pumila). Int Food Res J. 2011; 18:1021–6.

Seo WH, Baek HHJ. Identification of characteristic aroma active compounds from water dropwort (Oenanthe javanica DC). Agric Food Chem. 2005; 53:6766–70.

Chan EWC, Tan YP, Chin SC, Gan LY, Kang KX, Fong CH, et al. Antioxidant properties of selected fresh and processed herbs and vegetables. Free Radical Antioxid. 2014; 14:39–46.

Fatimah AMZ, Norazian MH, Rashidi O. Identification of carotenoid composition in selected ‘ulam' or traditional vegetables in Malaysia. Int Food Res J. 2012; 19:527–30.

Kongkachuichai R, Charoensiri R, Yakoh K, Kringkasemsee A, Insung P. Nutrients value and antioxidant content of indigenous vegetables from Southern Thailand. Food Chem. 2015; 173:838–46.

Hwang CR, Hwang IG, Kim HY, Kang TS, Kim YB, Joo SS, et al. Antioxidant component and activity of dropwort (Oenanthe javanica) ethanol extracts. J Korean Soc Food Sci Nutr. 2011; 40:316–20.

Tae HJ, Park JH, Cho JH, Kim IH, Ahn JH, Lee JC, et al. Oenanthe javanica extract increases immunoreactivities of antioxidant enzymes in the rat kidney. Chin Med J. 2014; 127:3758–63.

Tan YP. Antioxidant, antityrosinase, antibacterial and anti-quorum sensing activities of selected ulam herbs in Malaysia [MSc thesis]. Malaysia: UCSI University; 2013. p. 141.

Wahab NAA, Zain MSM, Kader J, Radzi SM, Noor, HM. Study of selected on anti-quorum sensing potential local ulam in Malaysia. World J Pharm Pharm Sci. 2014; 3:203– 11.

Kwon EJ, Kim MM. Effect of Oenanthe javanica ethanolic extracts on antioxidant activity and melanogenesis in melanoma cells. J Life Sci. 2013; 23:1428–35.

Tan YP, Chan EWC. Antioxidant, antityrosinase and antibacterial properties of fresh and processed leaves of Anacardium occidentale and Piper betle. Food Biosci. 2014; 6:17–23.

Chiang SH, Chen YS, Hung MS, Lee SM, Lin CC. The enhancement effect of Salvia miltiorrhiza on melanin production of B16F10 melanoma cells. J Med Plant Res. 2012; 6:4338–42.

Yang XB, Huang ZM, Cao WB, Zheng M, Chen HY, Zhang JG. Antidiabetic effect of Oenanthe javanica flavone. Acta Pharmacol Sin. 2000; 21:239–42.

Yoshida J, Seino H, Ito Y, Nakano T, Satoh T, Ogane Y, et al. Inhibition of glycogen synthase kinase-3β by falcarindiolisolated from Japanese parsley (Oenanthe javanica). J Agric Food Chem. 2013; 61:7515–21.

Ji G, Yao X, Zang Z, Huang Z. Antiarrhythmic effect of Oenanthe javanica (Bl.) DC injection. J Chin Mater Med. 1990; 5:429–31.

Kim TH, Ku KS, Bae JS. Anti-inflammatory activities of isorhamnetin-3-O-galactoside against HMGB1-induced inflammatory responses in both HUVECs and CLPinduced septic mice. J Cell Biochem. 2013; 114:336–45.

Kim TH, Ku SK, Bae JS. Persicarin is anti-inflammatory mediator against HMGB1-induced inflammatory responses in HUVECs and in CLP-induced sepsis mice. J Cell Physiol. 2013; 228:696–703.

Lee JM, Kim NJ, Cho DH, Chung MY, Hwang KT, Kim HJ, et al. Ethanol extract of Oenanthe javanica modulates inflammatory response by inhibiting NF-ć¸B mediated cyclooxygenase-2 expression in RAW 264.7 macrophage. Food Sci Biotechnol. 2006; 15:303–7.

Yang JH, Kim SC, Shin BY, Jin SH, Jo MJ, Jegal KH, et al. O-methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-ć¸B activation. Food Chem Toxicol. 2013; 59:362–72.

Park JH, Cho JH, Kim IH, Ahn JH, Lee JC, Chen BH, et al. Oenanthe javanica extract protects against experimentally induced ischemic neuronal damage via its antioxidant effects. Chin Med J. 2015; 128:2932–7.

Chen BH, Park JH, Cho JH, Kim IH, Shin BN, Ahn JH, et al. Ethanol extract of Oenanthe javanica increases cell proliferation and neuroblast differentiation in the adolescent rat dentate gyrus. Neural Regen Res. 2015; 10:271–6.

Park JC, Choi JW. Effects of methanol extract of Oenanthe javanica on the hepatic alcohol metabolizing enzyme system and its bioactive component. Phytother Res. 1997; 11:260–2.

Cho HW, Kim MH, Hwang KY, Min BW, Park JC, Kim JH. Effects of Oenanthe javanica extracts on mercury accumulation in organs of the mouse. J Toxicol Publ Health. 1999; 15:1–8.

Ku SK, Kim TH, Bae JS. Anticoagulant activities of persicarin and isorhamnetin. Vasc Pharmacol. 2013; 58:272–9.

Ku SK, Kim TH, Lee S, Kim SM, Bae JS. Antithrombotic and profibrinolytic activities of isorhamnetin-3-Ogalactoside and hyperoside. Food Chem Toxicol. 2013; 53:197–204.

Lee SI, Park YS, Cho SY. Protective effect of Oenanthe javanica on the carbon tetrachloride-induced hepatotoxicity in mice. J Korean Soc Food Sci Nutr. 1993; 22:392–7.

Park JC, Yu YB, Lee JH, Hattori M, Lee CK, Choi JW. Protective effect of Oenanthe javanica on the hepatic lipid peroxidation in bromobenzene-treated rats and its bioactive component. Planta Med. 1996; 62:488–90.

Park JC, Kim JY, Lee YJ, Lee JS, Kim BG, Lee SH, et al. Protective effect of Oenanthe javanica extract on acetaminophen-induced hepatotoxicity in rats. Yakhak Hoeji. 2008; 54:316–21.

Lee CH, Park JH, Cho JH, Kim IH, Ahn JH, Lee JC, et al. Effect of Oenanthe javanica extract on antioxidant enzyme in the rat liver. Chin Med J. 2015; 128:1649–54.

Ai G, Huang ZM, Liu QC, Han YQ, Chen X. The protective effect of total phenolics from Oenanthe javanica on acute liver failure induced by D-galactosamine. J Ethnopharmacol. 2016; 186:53–60.

Yang SA, Jung YS, Lee SJ, Park SC, Kim MJ, Lee EJ, et al. Hepatoprotective effects of fermented field waterdropwort (Oenanthe javanica) extract and its major constituents. Food Chem Toxicol. 2014; 67:154–60.

Sun ZX, Liu S, Zhao AQ, Su RQ. Protective effect of chlorogenic acid against carbon tetrachloride-induced acute liver damage in rats. Chin Herbal Med. 2014; 6:36– 41.

Choi H, You Y, Hwang K, Lee J, Chun J, Chung JW, et al. Isolation and identification of compound from dropwort (Oenanthe javanica) with protective potential against oxidative stress in HepG2 cells. Food Sci Biotechnol. 2011; 20:1743–6.

Dong GZ, Lee JH, Ki SH, Yang JH, Cho IJ, Kang SH, et al. AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction. Eur J Pharmacol. 2014; 740:634–40.

Lee MK, Yang H, Ha NR, Sung SH, Kim YC. Isorhamnetin from Oenanthe javanica attenuates fibrosis in rat hepatic stellate cells via inhibition of ERK signaling pathway. Nat Prod Sci. 2008; 14:81–5.

Lee JY, Kim MY, Shin SH, Shin YO, Lee AR, Park CH, et al. Persicarin isolated from the Oenanthe javanica attenuates diabetes induced liver injury through the hyperglycemia upregulated NADPH oxidase activation. Integr Med Res. 2015; 4:75.

Han YQ, Huang ZM, Yang XB, Liu HZ, Wu GX. In vivo and in vitro anti-hepatitis B virus activity of total phenolics from Oenanthe javanica. J Ethnopharmacol. 2008; 118:148–53.

Wang WN, Yang XB, Liu HZ, Huang ZM, Wu GX. Effect of Oenanthe javanica flavone on human and duck hepatitis B virus infection. Acta Pharmacol Sin. 2005; 26:587–92.

Qi F, Wang Z, Cai P, Zhao L, Gao J, Kokudo N, et al. Traditional Chinese medicine and related active compounds: a review of their role on hepatitis B virus infection. Drug Discov Ther. 2013; 7:212–24.

Qiu LP, Chen KP. Anti-HBV agents derived from botanical origin. Fitoterapia. 2013; 84:140–57.

Won BY, Shin KY, Ha HJ, Chang KA, Yun YS, Kim YR, et al. Effect of dropwort (Oenanthe javanica) extracts on memory improvement in Alzheimer's disease animal model, Tg2576 mice. Korean J Food Sci Technol. 2015; 47:779–84.

Won BY, Shin KY, Ha HJ, Wee JH, Yun YS, Kim YR, et al. Inhibitory effects of dropwort (Oenanthe javanica) extracts on memory impairment and oxidative stress and the qualitative analysis of isorhamnetin in the extracts. J Korean Soc Food Sci Nutr. 2016; 45:1–11.

An ST, Choi YD, inventors; An ST, assignee. Production of tonic beverage composition. Korean patent 20020062806. 2004 Apr 4.

Jung GU, inventor; Daegun Food Co Ltd, assignee. Manufacturing method of alcohol detoxification beverage. Korean patent KR20030006670. 2004 Aug 11.

Lee IP, inventor; Lee IP, assignee. Minari extract for preventing the induction and metastasis of cancer by carcinogens contained in cigarette smoke, fermented foods or alcoholic drinks. United States patent US7273625. 2007 Sep 25.

Kim ES, Kim HJ, Lee GY, Lee JY, Sung SH, Yoon JS, inventors; Elcom Science Co Ltd, assignee. Composition for improving brain function and cognitive function of human. Korean patent KR20020042740. 2004 Jan 31.

Suh YH, Shin KY, Won BY, Lee HJ, Lee HG, Hee JK, et al., inventors; Braintropia Co Ltd, assignee. Composition containing Oenanthe javanica extract as an active ingredient for preventing or treating learning disabilities or memory disorders, and method for preparing same. World Intellectual Property Organization patent WO2011KR06591. 2012 Mar 15.

Suh YH, Shin KY, Won BY, Lee HJ, Lee HG, Jung KH, et al., inventors; Braintropia Co Ltd, assignee. Composition for treatment or prevention of learning or memory malfunctions comprising minari extract as an effective component and preparation method thereof. Korean patent KR20110090839. 2012 Mar 16.

Bodeker G. Health and beauty from the rainforest: Malaysian traditions of Ramuan. Kuala Lumpur: Didier Millet; 2009. p. 256.

Amna OF, Nooraain H, Noriham A, Azizah AH, Husna RN. Acute and oral subacute toxicity study of ethanolic extract of Cosmos caudatus leaf in Sprague Dawley rats. Int J Biosci Biochem Bioinfor. 2013; 3:301–5.

Rahman AHMM. An ethnobotanical investigation on Asteraceae family at Rajshahi, Bangladesh. J Busin Admin Manag Sci Res. 2013; 2:133–41.

Shui G, Leong LP, Wong SP. Rapid screening and characterisation of antioxidants of Cosmos caudatus using liquid chromatography coupled with mass spectrometry. J Chromatogr B. 2005; 827:127–38.

Mediani A, Abas F, Khatib A, Tan CP. Cosmos caudatus as a potential source of polyphenolic compounds: optimisation of oven drying conditions and characterisation of its functional properties. Molecules. 2013; 18:10452–64.

Abas F, Shaari K, Lajis NH, Israf DA, Kalsom YU. Antioxidative and radical scavenging properties of the constituents isolated from Cosmos caudatus Kunth. Nat Prod Sci. 2003; 9:245–8.

Andarwulan N, Batari R, Sandrasari DA, Bolling B, Wijaya H. Flavonoid content and antioxidant activity of vegetables from Indonesia. Food Chem. 2010; 121:1231–5.

Andarwulan N, Kurniasih D, Apriady RA, Rahmat H, Rotoc AV, Bolling BW. Polyphenols, carotenoids, and ascorbic acid in underutilized medicinal vegetables. J Funct Food. 2012; 4:339–47.

Lee TK, Vairappan CS. Antioxidant, antibacterial and cytotoxic activities of essential oils and ethanol extracts of selected South East Asian herbs. J Med Plant Res. 2011; 5:5284–90.

Dian-Nashiela F, Noriham A, Noorain H, Azizah AH. Antioxidant activity of herbal tea prepared from Cosmos caudatus leaves at different maturity stages. Int Food Res J. 2015; 22:1189–94.

Cheng SH, Khoo HE, Ismail A, Abdul-Hamid A, Barakatun-Nisak MY. Influence of extraction solvents on Cosmos caudatus leaf antioxidant properties. Iranian J Sci Technol. 2016; 40:51–8.

Rasdi NHM, Samah OA, Sule A, Ahmed QU. Antimicrobial studies of Cosmos caudatus Kunth. (Compositae). J Med Plant Res. 2010; 4:669–73.

Salehan NM, Meon S, Ismail IS. Antifungal activity of Cosmos caudatus extracts against seven economicallyimportant plant pathogens. Int J Agric Biol. 2013; 15:864– 70.

Ajaykumar TV, Anandarajagopal K, Sunilson AJ, Arshad A, Jainaf RAM, Venkateshan N. Anti-inflammatory activity of Cosmos caudatus. Int J Univ Pharm Bio Sci. 2012; 1:40–8.

Amalia L, Sukrasno AK, Fidrianny I, Inggriani R. Antihypertensive potency of wild cosmos (Cosmos caudatus Kunth, Asteraceae) leaf extract. J Pharmacol Toxicol. 2012; 7:359–68.

Radman HM, Yusof K, Saad QM, Ngah WZW, Abdullah A. The effect of ulam raja (Cosmos caudatus) on drugmetabolizing enzymes, lipid peroxidation and antioxidant status in mice liver. Int J Pharm Tech Res. 2014; 6:1213–25.

Abdullah A, Dhaliwal KK, Roslan NNF, Lee CH, Kalaiselvam M, Radman HM, et al. The effects of Cosmos caudatus (ulam raja) on detoxifying enzymes in extrahepatic organs in mice. J Appl Pharm Sci. 2015; 5:82–8.

Loh SP, Hadira O. In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension. Malay J Nutr. 2011; 17:77–86.

Mun'im A, Azizahwati K, Andriani A, Mahmudah KF, Mashita M. Screening of inhibitory activity of some Indonesian medicinal plants. Int J Med Aromat Plant. 2013; 3:144–50.

Javadi N, Abas F, Hamid A, Simoh S, Shaari K, Ismail IS. GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity. J Food Sci. 2014; 79:1130–6.

Mohamed N, Khee SGS, Shuid AN, Muhammad N, Suhaimi F, Othman F, et al. The effects of Cosmos caudatus on structural bone histomorphometry in ovariectomized rats. Evid-based Complement Altern Med. 2012; 817814:6.

Mohamed N, Sahhugi Z, Ramli ESM, Muhammad N. The effects of Cosmos caudatus (ulam raja) on dynamic and cellular bone histomorphometry in ovariectomized rats. BMC Res Notes. 2013; 6:239.

Mohamed N, Yin CM, Shuid AN, Muhammad N, Babji AS, Soelaiman IN. The effects of Cosmos caudatus (ulam raja) supplementation on bone biochemical parameters in ovariectomized rats. Pak J Pharm Sci. 2013; 26:1027–31.

Godspower PR, Mohamed N, Shuid AN. Cosmos caudatus enhances fracture healing in ovariectomised rats: a preliminary biomechanical evaluation. Int J Appl Res Nat Prod. 2015; 8:12–9.

Perumal V, Hamid AA, Ismail A, Shaari K, Abas F, Ismail IS, et al. Effect of Cosmos caudatus Kunth leaves on the lipid profile of a hyperlipidemia-induced animal model. J Food Chem Nutr. 2014; 2:43–51.

Norazlina M, Ehsan SZ, Noor Adilah K, Lee CP, Farhana E, Derick P, et al. Acute toxicity study of Cosmos caudatus on biochemical parameters in male rats. Sains Malaysiana. 2013; 42:1247–51.

Cheng SH, Ismail A, Anthony J, Ng OC, Hamid AA, Yusof BN. Effect of Cosmos caudatus (ulam raja) supplementation in patients with type 2 diabetes: study protocol for a randomized controlled trial. BMC Complement Altern Med. 2016; 16:84.

Cheng SH, Ismail A, Anthony J, Ng OC, Hamid AA, Barakatun-Nisak MY. Eight weeks of Cosmos caudatus (ulam raja) supplementation improves glycemic status in patients with type 2 diabetes: a randomized controlled trial. Evid-based Complement Altern Med. 2015; 405615:7.