Anti-Ulcer Activity of Stem Bark of Shorea tumbuggaia

Abstract

Objective: To study the anti-ulcer activity of stem bark of Shorea tumbuggaia in pylorus ligation method. Materials and method: Petroleum ether (60-80°), chloroform, ethanol and aqueous extract of Shorea tumbuggaia stem bark were tested for various preliminary phytoconstituents and were screened for anti-ulcer activities in pylorus ligation method in albino rats. Doses for the different extracts were selected based on the results of acute toxicity studies in mice. The effect was assessed by ulcer index, total acidity, free acidity, pH of gastric contents, serum calcium levels and serum alkaline phosphatase levels in pyloric ligation method. Result: Lipids, sterols, triterpenoids, tannins and phenol were found to be present in various extracts of Shorea tumbuggaia stem barks. The ethanolic extract of stem bark of Shorea tumbuggaia significantly raised the pH of gastric contents. It lowered the free acidity, total acidity and ulcer index as compared to control. It significantly raised the serum calcium levels and decreased the serum alkaline phosphates levels. Conclusion: From the results obtained it can be observed that ethanolic extract of stem bark of Shorea tumbuggaia has significant anti-ulcer property.