Inhibitory Effect of Prenylflavonoid in Euchresta japonica on Copper-Induced Protein Oxidative Modification In vitro


  • Kansai College of Oriental Medicine, Department of Pharmaceutical Science, Osaka, 5900482, Japan
  • Josai University, Faculty of Pharmaceutical Sciences, Saitama, 3500295, Japan


Objective: To investigate the inhibitory effect of prenylflavonoid, 5,7,4'-trihydroxy-6,8- diprenylisoflavone isolated from Euchresta japonica, on oxidative stress. Materials and methods: The inhibitory effect of 5,7,4'-trihydroxy-6,8-diprenylisoflavone was tested on copper-induced protein oxidative modification in vitro. Result: 5,7,4'-trihydroxy-6,8-diprenylisoflavone inhibited copperinduced protein oxidative modification. Its inhibitory effect was stronger than that of genistein as a non-prenylated isoflavone. Conclusion: The results demonstrated that prenylflavonoid, 5,7,4'-trihydroxy- 6,8-diprenylisoflavone isolated from Euchresta japonica, has inhibitory effect on oxidative stress as copper-induced protein oxidative modification in vitro.


5,7,4'-Trihydroxy-6,8-Diprenylisoflavone, Euchresta japonica, Copper, Protein Oxidative Modification.

Subject Discipline

Pharmacy and Pharmacology

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