Diuretic Activity of Cocos nucifera Husk in Rats


Affiliations

  • MAEER's Maharashtra Institute of Pharmacy, Department of Pharmacognosy, Pune, 38, India
  • Bharati Vidyapeeth Deemed University, Poona College of Pharmacy and Research Center, Department of Pharmacology, Pune, 38, India
  • Siddhant College of Pharmacy, Pune, 412109, India
  • Bharati Vidyapeeth Deemed University, Poona College of Pharmacy and Research Center, Department of Pharmacology, Pune, 411038, India

Abstract

Objective: Husk of Cocos nucifera was screened for diuretic properties. Method: The diuretic properties of aqueous and alcoholic extract of Cocos nucifera husk were evaluated by determination of urine volume, electrolyte concentration and diuretic potency in male albino rats. Different concentrations of aqueous and alcoholic extract (250 mg/kg, 500mg/kg) were orally administered to hydrated rats and their urine output was immediately measured after 5 h of treatment. Frusemide (10mg/kg) was used as reference drug while normal saline (0.9%) solution was used as control. Result: Both the extract exhibited dose dependent diuretic property. The onset of diuretic action was extremely prompt (within 1 h) and lasted throughout the studied period (upto 5 h). Both extract caused marked increase in Na+, K+ and Cl-level. Conclusion: The result of this experiment suggests that Cocos nucifera husk extract possessed significant diuretic activity.

Keywords

Cocos nucifera, Aqueous Extract, Alcohol Extract, Diuretic Activity.

Subject Discipline

Pharmacy and Pharmacology

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