The Effect of Garlic Oil on Lipid Peroxidation and Blood Cell Counts of Arsenic Exposed Albino Mice


Affiliations

  • PSG Institute of Medical Sciences and Research, Department of Physiology, Coimbatore, 641004, India
  • PSG Institute of Medical Sciences and Research, Department of Gastroenterology and Liver Unit and Biochemistry, Coimbatore, 641004, India

Abstract

Objective: This study was undertaken to investigate the antiperoxide effect of garlic oil on various tissues and blood cell counts of arsenic exposed albino mice. Materials and methods: Garlic oil (100 mg/ kg body wt/ day) removed from garlic pearls purchased from Ranbaxy was administered orally to albino mice and its protective effect was determined on sodium arsenite-induced lipid peroxidation (LPO) of different tissues and blood cell counts of mice. Results: A significant reduction in arsenicinduced LPO in the kidney of mice was observed after the administration of garlic oil. There was a significant increase in the number of neutrophils and eosinophils in mice administered with garlic oil. A significant weight gain observed in mice given sodium arsenite (i.p.) was found to be declined after the garlic oil administration. Conclusion: These results indicate that garlic oil can be administered in the form of garlic pearls to persons who are working in places of coal burning, mining and metal ore smelting, as the diallyl disulphide (DADS) which is the active principle of garlic has a possible protective role on LPO status of certain tissues and blood cell counts of arsenic exposed mice.

Keywords

Garlic Oil, Lipid Peroxidation, Arsenic-Exposed, Thiobarbituric Acid Reacting Substances, Diallyl Disulphide (DADS).

Subject Discipline

Pharmacy and Pharmacology

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