Amelioration of Methotrexate-Induced Testicular Toxicity in Rats by Two Varieties of Coconut Water: Effect on Sperm Characters, Oxidative Stress and Testosterone Levels

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Authors

  • Vanishree
     Department of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal – 576104, Karnataka ,IN
  • Balaji Ommurugan
     Bio Pharma Solutions, Chennai, Tamil Nadu ,IN
  • Shivaprakash Gangachannaiah
     Department of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal – 576104, Karnataka ,IN
  • M. Deepak Nayak
     Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal – 576104, Karnataka ,IN
  • Ravindra Maradi
     Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal – 576104, Karnataka ,IN
  • Nadeem Khan
     Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal – 576104, Karnataka ,IN
  • L. C. Pallavi
     Department of Physiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal – 576104, Karnataka ,IN

DOI:

https://doi.org/10.18311/jnr/2021/26014

Keywords:

Antioxidant, Coconut Water, Methotrexate, Sperm Function

Abstract

Methotrexate (MTX) is used as an anticancer drug in many types of cancer associated with organ toxicities. It generates free radicals responsible for tissue damage in organs like testis. Coconut water, a natural drink known for its nutritive values also possess components, which are rich in antioxidants. The present study was a novel study to evaluate the benefits of yellow and green varieties of coconut water in testicular damage caused by methotrexate in experimental animals. The study proved that, both the varieties of coconut water restored testicular structure and functions by recovering sperm function, testicular enzymes, antioxidant enzymes and improvement in tissue microscopy. We conclude that both green and yellow coconut water are beneficial and can be used as a natural remedy for methotrexate induced testicular toxicity.

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Published

2021-04-17

How to Cite

Vanishree, ., Ommurugan, B., Gangachannaiah, S., Deepak Nayak, M., Maradi, R., Khan, N., & Pallavi, L. C. (2021). Amelioration of Methotrexate-Induced Testicular Toxicity in Rats by Two Varieties of Coconut Water: Effect on Sperm Characters, Oxidative Stress and Testosterone Levels. Journal of Natural Remedies, 21(2), 133–140. https://doi.org/10.18311/jnr/2021/26014

Issue

Volume 21, Issue 2, April 2021

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2020-09-06
Accepted 2020-12-29
Published 2021-04-17

 

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