Efficacy of Bee Honey on Wound Healing: Split Skin Graft with Hyper-granulation Tissue


  • Princess Nourah Bint Abdulrahman University, College of Nursing, Medical Microbiology, Department of Medical Surgical, Riyadh, Saudi Arabia
  • Khartoum North Teaching Hospital, Clinical Surgery, MD Plastic Surgery and Reconstructive Surgery, Khartoum, Sudan


The present prospective study was aimed to evaluate the effectiveness of topical application of bee honey on wound healing with hyper granulation tissue of infected split skin graft. Methods: A 27 years old female was admitted to Khartoum North Teaching Hospital plastic surgery unit with painful swelling of the right buttock with localized heat, which was proved as a pyogenic abscess. Swabs were taken from the wound for isolation, identification and viable bacterial count. The abscess was drained under general anesthesia and dressed with saline and MEBO ointment (combination of honey and herbs). Skin graft was performed. After 2 weeks of MEBO dressing, the wound was infected and hyper granulation tissue was observed. Daily application of honey was used instead of MEBO ointment. Results: Isolated organism was identified as Staphylococcus aureus. In vitro antibacterial test of honey against the isolated organism exhibited strong antibacterial activity. After one week of honey dressing, bacterial growth was inhibited and finally the wound was free from S. aureus. After 2 weeks of honey dressing, wound healing with reduced, hyper- granulation tissue was found. Conclusion: Topical application of honey dressing on wound with hyper granulation tissue for 3 weeks resulted in clean sterile wound with healthy granulation tissue and prompt graft was observed. Complete wound healing was achieved and hyper granulation tissue was reduced without surgical interference.


Honey Dressing, Split Skin Graft with Hyper-granulation Tissue, Wound Healing

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